Islet amyloid polypeptide: Identification and chromosomal localization of the human gene

Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its ca...

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Veröffentlicht in:FEBS letters 1988-11, Vol.239 (2), p.227-232
Hauptverfasser: Mosselman, S., Höppener, J.W.M., Zandberg, J., van Mansfeld, A.D.M., van Kessel, A.H.M.Geurts, Lips, C.J.M., Jansz, H.S.
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Sprache:eng
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Zusammenfassung:Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80922-0