Effects of various peptides on isolated rabbit lower esophageal sphincter

Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced rel...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1996, Vol.17 (6), p.927-931
Hauptverfasser:	Kohjitani, Atsushi, Shirakawa, Junji, Okada, Saeko, Obara, Hidefumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Bombesin Bombesin - antagonists & inhibitors Bombesin - pharmacology Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - pharmacology Diphenhydramine - pharmacology Dose-Response Relationship, Drug Esophagogastric Junction - drug effects Lower esophageal sphincter Male Motilin Motilin - antagonists & inhibitors Motilin - pharmacology Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth - drug effects Neuropeptide Y Neuropeptide Y - pharmacology Peptides - pharmacology Phentolamine - pharmacology Propranolol - pharmacology Rabbit Rabbits Smooth muscle Substance P Substance P - pharmacology Vasoactive intestinal peptide Vasoactive Intestinal Peptide - antagonists & inhibitors Vasoactive Intestinal Peptide - pharmacology
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Zusammenfassung:	Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bombesin-induced contractions were antagonized by SP antagonist. VIP-induced relaxation was antagonized by phentolamine and VIP antagonist. Pretreatment withatropine, phentolamine, and diphenhydramine antagonized the motilin- and bombesin-induced contraction. Pretreatment with tetrodotoxin (TTX) attenuated the motilin- and bombesin-induced contraction, but not the SP-induced contraction and VIP-induced relaxation. EFS induced contraction, which was attenuated by TTX. Calcitonin gene-related peptide and neuropeptide Y had no effect on LES; however, they attenuated EFS-induced contraction. These findings suggest some characteristic peptidergic involvement in rabbit LES smooth muscle.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/0196-9781(96)00137-4