Sprouting of CGRP nerve fibers in response to dentin injury in rat molars

Light and electron microscopic immunocytochemistry showed extensive increases in the number of calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers subjacent to injured root dentin of rat molars. Sprouting was greatest at 4 days and returned to normal 10–21 days post injury. Non-CGR...

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Veröffentlicht in:	Brain research 1988-10, Vol.461 (2), p.371-376
Hauptverfasser:	Taylor, P.E., Byers, M.R., Redd, P.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal sprouting Biological and medical sciences Calcitonin Gene-Related Peptide Dentin - injuries Dentin - innervation Dentin - ultrastructure Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Microscopy, Electron Molar - injuries Neurogenic inflammation Neurons, Afferent - metabolism Neurons, Afferent - physiology Neurons, Afferent - ultrastructure Neuropeptides - metabolism Rats Rats, Inbred Strains Sensory receptor Time Factors Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Light and electron microscopic immunocytochemistry showed extensive increases in the number of calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers subjacent to injured root dentin of rat molars. Sprouting was greatest at 4 days and returned to normal 10–21 days post injury. Non-CGRP-IR fibers were also increased at 4 days. The result suggest that rapid reversible sprouting of sensory nerve fibers may be an integral part of tissue reactions to injury.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(88)90270-3