Development of an antivenom against toxins of Lonomia obliqua caterpillars

Skin contact with caterpillars of Lonomia moths causes haemostatic disorders that may evolve into a haemorrhagic syndrome. Replacement therapy has been shown to exacerbate the clinical symptoms of this envenoming. In this study it is shown that horses immunized with a bristle extract of L. obliqua c...

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Veröffentlicht in:	Toxicon (Oxford) 1996-09, Vol.34 (9), p.1045-1049
Hauptverfasser:	DIAS DA SILVA, W, ROCHA CAMPOS, A. C. M, GONCALVES, L. R. C, SOUSA-E-SILVA, M. C. C, HIGASHI, H. G, YAMAGUSHI, I. K, KELEN, E. M. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Antibody Formation Antibody Specificity Antivenins - chemistry Antivenins - isolation & purification Antivenins - metabolism Antivenins - pharmacology Arthropod Venoms Biological and medical sciences Blood Coagulation - drug effects Drug Design Hemorrhage - drug therapy Hemorrhage - prevention & control Hemostasis Horses Immunoglobulin G - metabolism Immunohistochemistry Lonomia obliqua Medical sciences Moths Rats Saturniidae Toxicology Vaccination
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Beschreibung
Zusammenfassung:	Skin contact with caterpillars of Lonomia moths causes haemostatic disorders that may evolve into a haemorrhagic syndrome. Replacement therapy has been shown to exacerbate the clinical symptoms of this envenoming. In this study it is shown that horses immunized with a bristle extract of L. obliqua caterpillars produced IgG antibodies that completely neutralized, in vitro, the toxin(s) responsible for the blood incoagulability observed in rats. This antivenom offers the possibility of specific treatment for envenoming caused by contact with caterpillars of Lonomia moths.
ISSN:	0041-0101
DOI:	10.1016/0041-0101(96)00052-9