Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats
The hypotensive peptide, adrenomedullin (AM), was first isolated from the tissue of human pheochromocytoma. Recently, AM-immunoreactivities have been found in the central nervous system, including the supraoptic and the paraventricular nuclei. In this study, the effect of centrally administered AM o...
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| Veröffentlicht in: | Neuroscience letters 1996-09, Vol.216 (1), p.65-67 |
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| creator | Yokoi, Hisashi Arima, Hiroshi Murase, Takashi Kondo, Kunikazu Iwasaki, Yasumasa Oiso, Yutaka |
| description | The hypotensive peptide, adrenomedullin (AM), was first isolated from the tissue of human pheochromocytoma. Recently, AM-immunoreactivities have been found in the central nervous system, including the supraoptic and the paraventricular nuclei. In this study, the effect of centrally administered AM on arginine vasopressin (AVP) release was investigated in conscious rats. Intracerebroventricular injection of AM (1.0 μg/rat) partially but significantly attenuated the plasma AVP increase induced by hyperosmolality (intraperitoneal (i.p.) injection of hypertonic saline (600 mosmol/kg)) at 30 min after the injection. It also significantly attenuated the plasma AVP increase induced by hypovolemia (i.p. injection of polyethylene glycol) at 30 min after the injection. These results suggest that central AM might play an inhibitory role in both osmo- and baro-regulation of plasma AVP. |
| doi_str_mv | 10.1016/0304-3940(96)12998-0 |
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Recently, AM-immunoreactivities have been found in the central nervous system, including the supraoptic and the paraventricular nuclei. In this study, the effect of centrally administered AM on arginine vasopressin (AVP) release was investigated in conscious rats. Intracerebroventricular injection of AM (1.0 μg/rat) partially but significantly attenuated the plasma AVP increase induced by hyperosmolality (intraperitoneal (i.p.) injection of hypertonic saline (600 mosmol/kg)) at 30 min after the injection. It also significantly attenuated the plasma AVP increase induced by hypovolemia (i.p. injection of polyethylene glycol) at 30 min after the injection. These results suggest that central AM might play an inhibitory role in both osmo- and baro-regulation of plasma AVP.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(96)12998-0</identifier><identifier>PMID: 8892393</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adrenomedullin ; Animals ; Antihypertensive Agents - pharmacology ; Arginine Vasopressin - metabolism ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Volume - drug effects ; Blood Volume - physiology ; Fundamental and applied biological sciences. Psychology ; Hyperosmolality ; Hypovolemia ; Injections, Intraventricular ; Intracerebroventricular injection ; Male ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Peptides - administration & dosage ; Peptides - pharmacology ; Polyethylene Glycols - pharmacology ; Rats ; Rats, Sprague-Dawley ; Saline Solution, Hypertonic ; Sodium - blood ; Vasopressin ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1996-09, Vol.216 (1), p.65-67</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-578ac0a750b2d0e9b28fc896042df6ac22ebce864d63799a28d019d906313e193</citedby><cites>FETCH-LOGICAL-c452t-578ac0a750b2d0e9b28fc896042df6ac22ebce864d63799a28d019d906313e193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(96)12998-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3231678$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8892393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokoi, Hisashi</creatorcontrib><creatorcontrib>Arima, Hiroshi</creatorcontrib><creatorcontrib>Murase, Takashi</creatorcontrib><creatorcontrib>Kondo, Kunikazu</creatorcontrib><creatorcontrib>Iwasaki, Yasumasa</creatorcontrib><creatorcontrib>Oiso, Yutaka</creatorcontrib><title>Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The hypotensive peptide, adrenomedullin (AM), was first isolated from the tissue of human pheochromocytoma. Recently, AM-immunoreactivities have been found in the central nervous system, including the supraoptic and the paraventricular nuclei. In this study, the effect of centrally administered AM on arginine vasopressin (AVP) release was investigated in conscious rats. Intracerebroventricular injection of AM (1.0 μg/rat) partially but significantly attenuated the plasma AVP increase induced by hyperosmolality (intraperitoneal (i.p.) injection of hypertonic saline (600 mosmol/kg)) at 30 min after the injection. It also significantly attenuated the plasma AVP increase induced by hypovolemia (i.p. injection of polyethylene glycol) at 30 min after the injection. These results suggest that central AM might play an inhibitory role in both osmo- and baro-regulation of plasma AVP.</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Arginine Vasopressin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Volume - drug effects</subject><subject>Blood Volume - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hyperosmolality</subject><subject>Hypovolemia</subject><subject>Injections, Intraventricular</subject><subject>Intracerebroventricular injection</subject><subject>Male</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - pharmacology</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Saline Solution, Hypertonic</subject><subject>Sodium - blood</subject><subject>Vasopressin</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSLfb_IMUfCilOTjVh62PS6GENgkEcmnPQpbGRMErbTX2Qv59tN1ljz0NM-8zw_AQcsXoDaNMfqOCdq0wHf1q5DXjxuiWnpEV04q3yij-jqxOyHvyAfGFUtqzvrsgF1obLoxYkeEhzcV5KDCUvIPaRL9MrjQxvYCfY05NHhsXCqS8gbBMU0w1e45DnLHZOczbAoh1WGACh1DDxueEPuYFm-Jm_EjORzchXB7rmvz59fP37X37-HT3cPvjsfVdz-e2V9p56lRPBx4omIHr0WsjacfDKJ3nHAYPWnZBCmWM4zpQZoKhUjABzIg1-XK4uy357wI4201ED9PkEtRfrNKdVr3pK9gdQF8yYoHRbkvcuPJqGbV7tXbvze69WSPtP7V1tCafjveXoao4LR1d1vzzMXfo3TQWl3zEEya4YFLpin0_YFBd7CIUW11B8hBiqcZtyPH_f7wB916W-w</recordid><startdate>19960920</startdate><enddate>19960920</enddate><creator>Yokoi, Hisashi</creator><creator>Arima, Hiroshi</creator><creator>Murase, Takashi</creator><creator>Kondo, Kunikazu</creator><creator>Iwasaki, Yasumasa</creator><creator>Oiso, Yutaka</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960920</creationdate><title>Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats</title><author>Yokoi, Hisashi ; Arima, Hiroshi ; Murase, Takashi ; Kondo, Kunikazu ; Iwasaki, Yasumasa ; Oiso, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-578ac0a750b2d0e9b28fc896042df6ac22ebce864d63799a28d019d906313e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Arginine Vasopressin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Volume - drug effects</topic><topic>Blood Volume - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hyperosmolality</topic><topic>Hypovolemia</topic><topic>Injections, Intraventricular</topic><topic>Intracerebroventricular injection</topic><topic>Male</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - pharmacology</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Saline Solution, Hypertonic</topic><topic>Sodium - blood</topic><topic>Vasopressin</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokoi, Hisashi</creatorcontrib><creatorcontrib>Arima, Hiroshi</creatorcontrib><creatorcontrib>Murase, Takashi</creatorcontrib><creatorcontrib>Kondo, Kunikazu</creatorcontrib><creatorcontrib>Iwasaki, Yasumasa</creatorcontrib><creatorcontrib>Oiso, Yutaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokoi, Hisashi</au><au>Arima, Hiroshi</au><au>Murase, Takashi</au><au>Kondo, Kunikazu</au><au>Iwasaki, Yasumasa</au><au>Oiso, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1996-09-20</date><risdate>1996</risdate><volume>216</volume><issue>1</issue><spage>65</spage><epage>67</epage><pages>65-67</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The hypotensive peptide, adrenomedullin (AM), was first isolated from the tissue of human pheochromocytoma. Recently, AM-immunoreactivities have been found in the central nervous system, including the supraoptic and the paraventricular nuclei. In this study, the effect of centrally administered AM on arginine vasopressin (AVP) release was investigated in conscious rats. Intracerebroventricular injection of AM (1.0 μg/rat) partially but significantly attenuated the plasma AVP increase induced by hyperosmolality (intraperitoneal (i.p.) injection of hypertonic saline (600 mosmol/kg)) at 30 min after the injection. It also significantly attenuated the plasma AVP increase induced by hypovolemia (i.p. injection of polyethylene glycol) at 30 min after the injection. These results suggest that central AM might play an inhibitory role in both osmo- and baro-regulation of plasma AVP.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8892393</pmid><doi>10.1016/0304-3940(96)12998-0</doi><tpages>3</tpages></addata></record> |
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| subjects | Adrenomedullin Animals Antihypertensive Agents - pharmacology Arginine Vasopressin - metabolism Biological and medical sciences Blood Pressure - drug effects Blood Volume - drug effects Blood Volume - physiology Fundamental and applied biological sciences. Psychology Hyperosmolality Hypovolemia Injections, Intraventricular Intracerebroventricular injection Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Peptides - administration & dosage Peptides - pharmacology Polyethylene Glycols - pharmacology Rats Rats, Sprague-Dawley Saline Solution, Hypertonic Sodium - blood Vasopressin Vertebrates: nervous system and sense organs |
| title | Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats |
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