Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats

Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats

The hypotensive peptide, adrenomedullin (AM), was first isolated from the tissue of human pheochromocytoma. Recently, AM-immunoreactivities have been found in the central nervous system, including the supraoptic and the paraventricular nuclei. In this study, the effect of centrally administered AM o...

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Veröffentlicht in:Neuroscience letters 1996-09, Vol.216 (1), p.65-67
Hauptverfasser: Yokoi, Hisashi, Arima, Hiroshi, Murase, Takashi, Kondo, Kunikazu, Iwasaki, Yasumasa, Oiso, Yutaka
Format: Artikel
Sprache:eng
Schlagworte:
Adrenomedullin
Animals
Antihypertensive Agents - pharmacology
Arginine Vasopressin - metabolism
Biological and medical sciences
Blood Pressure - drug effects
Blood Volume - drug effects
Blood Volume - physiology
Fundamental and applied biological sciences. Psychology
Hyperosmolality
Hypovolemia
Injections, Intraventricular
Intracerebroventricular injection
Male
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Peptides - administration & dosage
Peptides - pharmacology
Polyethylene Glycols - pharmacology
Rats
Rats, Sprague-Dawley
Saline Solution, Hypertonic
Sodium - blood
Vasopressin
Vertebrates: nervous system and sense organs
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Zusammenfassung:The hypotensive peptide, adrenomedullin (AM), was first isolated from the tissue of human pheochromocytoma. Recently, AM-immunoreactivities have been found in the central nervous system, including the supraoptic and the paraventricular nuclei. In this study, the effect of centrally administered AM on arginine vasopressin (AVP) release was investigated in conscious rats. Intracerebroventricular injection of AM (1.0 μg/rat) partially but significantly attenuated the plasma AVP increase induced by hyperosmolality (intraperitoneal (i.p.) injection of hypertonic saline (600 mosmol/kg)) at 30 min after the injection. It also significantly attenuated the plasma AVP increase induced by hypovolemia (i.p. injection of polyethylene glycol) at 30 min after the injection. These results suggest that central AM might play an inhibitory role in both osmo- and baro-regulation of plasma AVP.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(96)12998-0