Monoclonal gammopathy and antibody activity against the acetylcholine receptor

A 50‐year‐old woman with muscular fatigue and monoclonal gammopathy of unknown significance was shown to have high levels of antibodies against the acetylcholine receptor of the skeletal muscle endplate. The specific antibody activity was exclusively associated with the monoclonal component. There w...

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Veröffentlicht in:	American journal of hematology 1988-09, Vol.29 (1), p.49-51
Hauptverfasser:	Ahlberg, Richard E., Lefvert, Ann Kari
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine receptor antibodies Antibodies, Anti-Idiotypic - analysis Autoantibodies - analysis Autoantibodies - immunology Biological and medical sciences Cholinesterase Inhibitors - therapeutic use Electromyography Female Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulin G - immunology Immunoglobulinopathies Immunopathology Medical sciences MGUS Middle Aged myasthenia gravis Myasthenia Gravis - complications Myasthenia Gravis - physiopathology Paraproteinemias - complications Paraproteinemias - drug therapy Paraproteinemias - immunology Receptors, Cholinergic - immunology
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Beschreibung
Zusammenfassung:	A 50‐year‐old woman with muscular fatigue and monoclonal gammopathy of unknown significance was shown to have high levels of antibodies against the acetylcholine receptor of the skeletal muscle endplate. The specific antibody activity was exclusively associated with the monoclonal component. There were no objective signs of myasthenia gravis. This is the first reported case with antibody activity against the acetylcholine receptor found in a monoclonal immunoglobulin fraction.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830290112