A gene encoding a yeast equivalent of mammalian NADPH-adrenodoxin oxidoreductases

Adrenodoxin oxidoreductase (ADR) and adrenodoxin (ADX) are the two proteins involved in electron transport to mammalian mitochondrial P-450s capable of steroid modifications. The cloning and sequencing of a S. cervisiae ADR homologue ( YADR) is presented here. The YADR protein sequence shares 36 and...

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Veröffentlicht in:	Gene 1996, Vol.174 (2), p.289-292
Hauptverfasser:	Lacour, Thierry, Dumas, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenodoxin oxidoreductase Amino Acid Sequence amino acid sequences Animals Base Sequence Cattle Cloning, Molecular comparisons cytochrome P-450 Ferredoxin-NADP Reductase - genetics genbank/u38689 Genes, Fungal Humans Molecular Sequence Data nucleotide sequences P-450 S cerevisiae Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Sequence homology Sequence Homology, Amino Acid structural genes unspecific monooxygenase
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Zusammenfassung:	Adrenodoxin oxidoreductase (ADR) and adrenodoxin (ADX) are the two proteins involved in electron transport to mammalian mitochondrial P-450s capable of steroid modifications. The cloning and sequencing of a S. cervisiae ADR homologue ( YADR) is presented here. The YADR protein sequence shares 36 and 37% of identical amino acids with human and bovine ADR respectively. The physiological role of this ADR homologue in yeast is unknown. We intend to study the interaction of this YADR with bovine ADX in vitro and in vivo.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/0378-1119(96)00041-8