Male SJL mice do not relapse after induction of EAE with PLP 139-151

SJL mice immunized with proteolipid protein (PLP) develop relapsing experimental autoimmune encephalomyelitis (R‐EAE). R‐EAE is a CD4+, Th1 cell‐mediated demyelinating disease of the central nervous system (CNS) that is used as a model for the human disease multiple sclerosis (MS). Previous studies...

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Veröffentlicht in:	Journal of neuroscience research 1996-09, Vol.45 (6), p.680-689
Hauptverfasser:	Bebo Jr, B.F., Vandenbark, A.A., Offner, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Division - immunology cytokine Encephalomyelitis, Autoimmune, Experimental - immunology Epitopes Female Freund's Adjuvant Immunization Immunodominant Epitopes - immunology Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Male Mice Mice, Inbred Strains Molecular Sequence Data Myelin Proteins - immunology Myelin Proteolipid Protein Peptide Fragments - immunology proteolipid protein Recurrence relapsing experimental autoimmune encephalomyelitis Sex Characteristics sex differences in autoimmunity T-Lymphocytes - cytology T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	SJL mice immunized with proteolipid protein (PLP) develop relapsing experimental autoimmune encephalomyelitis (R‐EAE). R‐EAE is a CD4+, Th1 cell‐mediated demyelinating disease of the central nervous system (CNS) that is used as a model for the human disease multiple sclerosis (MS). Previous studies showed that young (
ISSN:	0360-4012 1097-4547
DOI:	10.1002/(SICI)1097-4547(19960915)45:6<680::AID-JNR4>3.0.CO;2-4