Cytotoxic Cardenolides from Woods of Euonymus alata

Three cytotoxic cardenolides, acovenosigenin A 3-O-α-L-ramnopyranoside (1), euonymoside A (2) and euonymusoside A (3), were isolated from the woods of Euonymus alata (Celastraceae). The chemical structure of a new cardenolide, euonymusoside A (3) has been elucidated on the basis of extensive spectra...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1996/03/15, Vol.44(3), pp.615-617
Hauptverfasser: KITANAKA, Susumu, TAKIDO, Michio, MIZOUE, Kazutoshi, NAKAIKE, Shiro
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Sprache:eng
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Zusammenfassung:Three cytotoxic cardenolides, acovenosigenin A 3-O-α-L-ramnopyranoside (1), euonymoside A (2) and euonymusoside A (3), were isolated from the woods of Euonymus alata (Celastraceae). The chemical structure of a new cardenolide, euonymusoside A (3) has been elucidated on the basis of extensive spectral analysis and enzymic hydrolysis to be acovenosigenin A (1β, 3β, 14β-trihydroxy-5β-cardenolide) 3-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl(1→4)-α-L-rhamnopyranoside. All three showed potent cytotoxic activity against some neoplastic cell lines.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.44.615