Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney

Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney. Expression of HSP-27, HSP-60 and HSP-70 was estimated in the cortex, outer medulla and inner medulla (papilla) of rats undergoing water diuresis or water restriction for two days. The mRNAs for HSP-27...

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Veröffentlicht in:	Kidney international 1996-10, Vol.50 (4), p.1191-1194
Hauptverfasser:	Medina, Ruth, Cantley, Lloyd, Spokes, Kate, Epstein, Franklin H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Blotting, Western Chaperonin 60 - genetics Chaperonin 60 - metabolism Diuresis - physiology Fundamental and applied biological sciences. Psychology Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Kidney - drug effects Kidney - metabolism Kidney Cortex - physiology Kidney Medulla - physiology Male Rats Rats, Sprague-Dawley RNA, Messenger - analysis Vertebrates: urinary system Water Deprivation - physiology
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Zusammenfassung:	Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney. Expression of HSP-27, HSP-60 and HSP-70 was estimated in the cortex, outer medulla and inner medulla (papilla) of rats undergoing water diuresis or water restriction for two days. The mRNAs for HSP-27 and HSP-60 in renal papilla were two- to threefold greater in rats during water restriction than in those excreting a dilute urine, but levels of mRNA for HSP-70 were not reduced by water diuresis and Western analysis for HSP-70 protein showed no difference between water-loaded and water-restricted animals.
ISSN:	0085-2538 1523-1755
DOI:	10.1038/ki.1996.427