Skin blood flow disturbances in the contralateral limb in a peripheral mononeuropathy in the rat
Electrical excitation of nociceptive afferents in an extremity has been demonstrated to increase skin blood flow in the contralateral extremity. Hence, one would expect that loose sciatic nerve ligation, which induces an experimental painful peripheral neuropathy, may also provoke a vasodilator resp...
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| Veröffentlicht in: | Neuroscience 1996-10, Vol.74 (3), p.935-943 |
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| creator | Kurvers, H.A.J.M Tangelder, G.J De Mey, J.G.R Slaaf, D.W van den Wildenberg, F.A.J.M Kitslaar, P.J.E.H.M Reneman, R.S Rouwet, E.V Jacobs, M.J.H.M |
| description | Electrical excitation of nociceptive afferents in an extremity has been demonstrated to increase skin blood flow in the contralateral extremity. Hence, one would expect that loose sciatic nerve ligation, which induces an experimental painful peripheral neuropathy, may also provoke a vasodilator response in the contralateral hindpaw. On the non-ligated side, such a response may involve inhibited skin vasoconstrictor activity as well as neurogenically mediated active vasodilation. We studied skin blood flow changes in the rat hindpaw consequent to contralateral loose sciatic nerve ligation. After ligation, we also investigated whether blockade of afferent input from the ligated sciatic nerve to the spinal cord, by means of lidocaine, overrules the vasodilator response in the non-ligated paw. On the non-ligated side, we assessed the vasoconstrictor response of skin microvessels to cooling of the rat abdomen as a measure of skin vasoconstrictor activity in this paw. In order to investigate the involvement of sensory and/or non-sensory nerve fibers in the non-ligated sciatic nerve on skin blood flow abnormalities in the non-ligated paw, we studied the influence of blockade of these fibers through successive capsaicin and lidocaine application. We show that loose ligation of the sciatic nerve induces a vasodilator response in the contralateral hindpaw, which is completely abolished by blockade of afferent input from the ligated sciatic nerve. From day 1 after ligation, skin vasoconstrictor activity in the non-ligated paw was reduced, as indicated by an impaired vasoconstrictor response to cooling of the rat abdomen. Beside, blockade of sensory but not of non-sensory nerve fibers on the non-ligated side attenuated the vasodilator response in this paw.
The data presented here indicate that loose ligation of the rat sciatic nerve induces a vasodilator response in the contralateral hindpaw. On the non-ligated side, this vasodilator response may involve inhibition of skin vasoconstrictor activity, as well as antidromically acting sensory nerve fibers. |
| doi_str_mv | 10.1016/0306-4522(96)00178-9 |
| format | Article |
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The data presented here indicate that loose ligation of the rat sciatic nerve induces a vasodilator response in the contralateral hindpaw. On the non-ligated side, this vasodilator response may involve inhibition of skin vasoconstrictor activity, as well as antidromically acting sensory nerve fibers.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(96)00178-9</identifier><identifier>PMID: 8884788</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Capsaicin - pharmacology ; chronic constriction injury ; Cold Temperature ; contralateral extremity ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Electric Stimulation ; Functional Laterality ; Hindlimb - blood supply ; Hindlimb - innervation ; Lidocaine - pharmacology ; Male ; Medical sciences ; nerve block ; Nerve Fibers - physiology ; Nervous system (semeiology, syndromes) ; Neurology ; Neurons, Afferent - physiology ; Pain ; Peripheral Nervous System Diseases - physiopathology ; Rats ; Rats, Inbred Lew ; reflex sympathetic dystrophy ; Regional Blood Flow ; Sciatic Nerve - physiology ; Skin - blood supply ; skin blood flow ; Spinal Cord - drug effects ; Spinal Cord - physiology ; Time Factors ; Ultrasonography, Doppler ; Vasoconstriction - drug effects ; Vasodilation - drug effects</subject><ispartof>Neuroscience, 1996-10, Vol.74 (3), p.935-943</ispartof><rights>1996 IBRO</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-ef93d8a7c628d176dcc1ce04c2c712a88f8b83bd067bdabec65f2912ff999e153</citedby><cites>FETCH-LOGICAL-c498t-ef93d8a7c628d176dcc1ce04c2c712a88f8b83bd067bdabec65f2912ff999e153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0306-4522(96)00178-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3203313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8884788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurvers, H.A.J.M</creatorcontrib><creatorcontrib>Tangelder, G.J</creatorcontrib><creatorcontrib>De Mey, J.G.R</creatorcontrib><creatorcontrib>Slaaf, D.W</creatorcontrib><creatorcontrib>van den Wildenberg, F.A.J.M</creatorcontrib><creatorcontrib>Kitslaar, P.J.E.H.M</creatorcontrib><creatorcontrib>Reneman, R.S</creatorcontrib><creatorcontrib>Rouwet, E.V</creatorcontrib><creatorcontrib>Jacobs, M.J.H.M</creatorcontrib><title>Skin blood flow disturbances in the contralateral limb in a peripheral mononeuropathy in the rat</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Electrical excitation of nociceptive afferents in an extremity has been demonstrated to increase skin blood flow in the contralateral extremity. Hence, one would expect that loose sciatic nerve ligation, which induces an experimental painful peripheral neuropathy, may also provoke a vasodilator response in the contralateral hindpaw. On the non-ligated side, such a response may involve inhibited skin vasoconstrictor activity as well as neurogenically mediated active vasodilation. We studied skin blood flow changes in the rat hindpaw consequent to contralateral loose sciatic nerve ligation. After ligation, we also investigated whether blockade of afferent input from the ligated sciatic nerve to the spinal cord, by means of lidocaine, overrules the vasodilator response in the non-ligated paw. On the non-ligated side, we assessed the vasoconstrictor response of skin microvessels to cooling of the rat abdomen as a measure of skin vasoconstrictor activity in this paw. In order to investigate the involvement of sensory and/or non-sensory nerve fibers in the non-ligated sciatic nerve on skin blood flow abnormalities in the non-ligated paw, we studied the influence of blockade of these fibers through successive capsaicin and lidocaine application. We show that loose ligation of the sciatic nerve induces a vasodilator response in the contralateral hindpaw, which is completely abolished by blockade of afferent input from the ligated sciatic nerve. From day 1 after ligation, skin vasoconstrictor activity in the non-ligated paw was reduced, as indicated by an impaired vasoconstrictor response to cooling of the rat abdomen. Beside, blockade of sensory but not of non-sensory nerve fibers on the non-ligated side attenuated the vasodilator response in this paw.
The data presented here indicate that loose ligation of the rat sciatic nerve induces a vasodilator response in the contralateral hindpaw. On the non-ligated side, this vasodilator response may involve inhibition of skin vasoconstrictor activity, as well as antidromically acting sensory nerve fibers.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Capsaicin - pharmacology</subject><subject>chronic constriction injury</subject><subject>Cold Temperature</subject><subject>contralateral extremity</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Electric Stimulation</subject><subject>Functional Laterality</subject><subject>Hindlimb - blood supply</subject><subject>Hindlimb - innervation</subject><subject>Lidocaine - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>nerve block</subject><subject>Nerve Fibers - physiology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neurons, Afferent - physiology</subject><subject>Pain</subject><subject>Peripheral Nervous System Diseases - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>reflex sympathetic dystrophy</subject><subject>Regional Blood Flow</subject><subject>Sciatic Nerve - physiology</subject><subject>Skin - blood supply</subject><subject>skin blood flow</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - physiology</subject><subject>Time Factors</subject><subject>Ultrasonography, Doppler</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasodilation - drug effects</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFvFCEYhkmjabe1_6AmczBGD1NhYAa4mJjGWpMmHlrPyMBHFp0ZRmA0_fdluts9lgME3uf9Qh6ELgi-JJh0nzDFXc3apvkgu48YEy5qeYQ2RHBa85axV2hzQE7QaUq_cVkto8foWAjBuBAb9Ovuj5-qfgjBVm4I_yvrU15irycDqSpR3kJlwpSjHnSGsleDH_s10dUM0c_bp8cxTGGCJYZZ5-3DczHq_Aa9dnpIcL4_z9DP66_3Vzf17Y9v36--3NaGSZFrcJJaobnpGmEJ76wxxABmpjGcNFoIJ3pBe4s73lvdg-la10jSOCelBNLSM_R-N3eO4e8CKavRJwPDoCcIS1JcsI6KVhSQ7UATQ0oRnJqjH3V8UASrVaxaranVmpLlsopVstTe7ucv_Qj2UNqbLPm7fa6T0YOLxaBPB4w2mFJCC_Z5h0Fx8c9DVMl4KLKtj2CyssG__I9HM6KVtQ</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Kurvers, H.A.J.M</creator><creator>Tangelder, G.J</creator><creator>De Mey, J.G.R</creator><creator>Slaaf, D.W</creator><creator>van den Wildenberg, F.A.J.M</creator><creator>Kitslaar, P.J.E.H.M</creator><creator>Reneman, R.S</creator><creator>Rouwet, E.V</creator><creator>Jacobs, M.J.H.M</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>Skin blood flow disturbances in the contralateral limb in a peripheral mononeuropathy in the rat</title><author>Kurvers, H.A.J.M ; Tangelder, G.J ; De Mey, J.G.R ; Slaaf, D.W ; van den Wildenberg, F.A.J.M ; Kitslaar, P.J.E.H.M ; Reneman, R.S ; Rouwet, E.V ; Jacobs, M.J.H.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-ef93d8a7c628d176dcc1ce04c2c712a88f8b83bd067bdabec65f2912ff999e153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Capsaicin - pharmacology</topic><topic>chronic constriction injury</topic><topic>Cold Temperature</topic><topic>contralateral extremity</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Electric Stimulation</topic><topic>Functional Laterality</topic><topic>Hindlimb - blood supply</topic><topic>Hindlimb - innervation</topic><topic>Lidocaine - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>nerve block</topic><topic>Nerve Fibers - physiology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neurons, Afferent - physiology</topic><topic>Pain</topic><topic>Peripheral Nervous System Diseases - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>reflex sympathetic dystrophy</topic><topic>Regional Blood Flow</topic><topic>Sciatic Nerve - physiology</topic><topic>Skin - blood supply</topic><topic>skin blood flow</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - physiology</topic><topic>Time Factors</topic><topic>Ultrasonography, Doppler</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasodilation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurvers, H.A.J.M</creatorcontrib><creatorcontrib>Tangelder, G.J</creatorcontrib><creatorcontrib>De Mey, J.G.R</creatorcontrib><creatorcontrib>Slaaf, D.W</creatorcontrib><creatorcontrib>van den Wildenberg, F.A.J.M</creatorcontrib><creatorcontrib>Kitslaar, P.J.E.H.M</creatorcontrib><creatorcontrib>Reneman, R.S</creatorcontrib><creatorcontrib>Rouwet, E.V</creatorcontrib><creatorcontrib>Jacobs, M.J.H.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurvers, H.A.J.M</au><au>Tangelder, G.J</au><au>De Mey, J.G.R</au><au>Slaaf, D.W</au><au>van den Wildenberg, F.A.J.M</au><au>Kitslaar, P.J.E.H.M</au><au>Reneman, R.S</au><au>Rouwet, E.V</au><au>Jacobs, M.J.H.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin blood flow disturbances in the contralateral limb in a peripheral mononeuropathy in the rat</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>74</volume><issue>3</issue><spage>935</spage><epage>943</epage><pages>935-943</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Electrical excitation of nociceptive afferents in an extremity has been demonstrated to increase skin blood flow in the contralateral extremity. Hence, one would expect that loose sciatic nerve ligation, which induces an experimental painful peripheral neuropathy, may also provoke a vasodilator response in the contralateral hindpaw. On the non-ligated side, such a response may involve inhibited skin vasoconstrictor activity as well as neurogenically mediated active vasodilation. We studied skin blood flow changes in the rat hindpaw consequent to contralateral loose sciatic nerve ligation. After ligation, we also investigated whether blockade of afferent input from the ligated sciatic nerve to the spinal cord, by means of lidocaine, overrules the vasodilator response in the non-ligated paw. On the non-ligated side, we assessed the vasoconstrictor response of skin microvessels to cooling of the rat abdomen as a measure of skin vasoconstrictor activity in this paw. In order to investigate the involvement of sensory and/or non-sensory nerve fibers in the non-ligated sciatic nerve on skin blood flow abnormalities in the non-ligated paw, we studied the influence of blockade of these fibers through successive capsaicin and lidocaine application. We show that loose ligation of the sciatic nerve induces a vasodilator response in the contralateral hindpaw, which is completely abolished by blockade of afferent input from the ligated sciatic nerve. From day 1 after ligation, skin vasoconstrictor activity in the non-ligated paw was reduced, as indicated by an impaired vasoconstrictor response to cooling of the rat abdomen. Beside, blockade of sensory but not of non-sensory nerve fibers on the non-ligated side attenuated the vasodilator response in this paw.
The data presented here indicate that loose ligation of the rat sciatic nerve induces a vasodilator response in the contralateral hindpaw. On the non-ligated side, this vasodilator response may involve inhibition of skin vasoconstrictor activity, as well as antidromically acting sensory nerve fibers.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8884788</pmid><doi>10.1016/0306-4522(96)00178-9</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Capsaicin - pharmacology chronic constriction injury Cold Temperature contralateral extremity Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Electric Stimulation Functional Laterality Hindlimb - blood supply Hindlimb - innervation Lidocaine - pharmacology Male Medical sciences nerve block Nerve Fibers - physiology Nervous system (semeiology, syndromes) Neurology Neurons, Afferent - physiology Pain Peripheral Nervous System Diseases - physiopathology Rats Rats, Inbred Lew reflex sympathetic dystrophy Regional Blood Flow Sciatic Nerve - physiology Skin - blood supply skin blood flow Spinal Cord - drug effects Spinal Cord - physiology Time Factors Ultrasonography, Doppler Vasoconstriction - drug effects Vasodilation - drug effects |
| title | Skin blood flow disturbances in the contralateral limb in a peripheral mononeuropathy in the rat |
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