Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea pig hippocampus

Samples collected from rabbit neocortical surface during a tetanic stimulation of the neocortex induced neurite growth in PC-12 cells in culture and synaptic long-term potentiation (LTP) in guinea pig hippocampal slices. If these samples were preheated and cooled, or if they were collected in the ab...

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Veröffentlicht in:	Neuroscience letters 1988-08, Vol.91 (1), p.101-105
Hauptverfasser:	Sastry, B.R., Chirwa, S.S., May, P.B.Y., Maretić, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Biological and medical sciences Cells, Cultured Central nervous system Cerebral Cortex - metabolism Cerebral Cortex - physiology Electric Stimulation Electrophysiology Evoked Potentials Fundamental and applied biological sciences. Psychology Guinea pig Guinea Pigs Hippocampus Hippocampus - drug effects Hippocampus - physiology Long-term potentiation Nerve Growth Factors Neurite growth PC-12 cell Peptides - metabolism Peptides - pharmacology Pheochromocytoma Rabbits Rats Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - physiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Samples collected from rabbit neocortical surface during a tetanic stimulation of the neocortex induced neurite growth in PC-12 cells in culture and synaptic long-term potentiation (LTP) in guinea pig hippocampal slices. If these samples were preheated and cooled, or if they were collected in the absence of a tetanic stimulation of the rabbit neocortex, they did not induce neurite growth in PC-12 cells or LTP in the guinea pig hippocampus. These results suggest that neurite-inducing factors are released during tetanic stimulations and that these substances are involved in LTP.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(88)90256-X