Ability of Different Flavonoids To Inhibit the Procoagulant Activity of Adherent Human Monocytes

Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1β in vitro. Eighteen of these compounds inhibited the interleukin-1β-induced expression of tissue factor...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1996-03, Vol.59 (3), p.273-276
Hauptverfasser:	Lale, A, Herbert, J. M, Augereau, J. M, Billon, M, Leconte, M, Gleye, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Blood Coagulation - drug effects Blood. Blood coagulation. Reticuloendothelial system Cell Adhesion - drug effects Endotoxins - pharmacology Flavonoids - pharmacology Humans In Vitro Techniques Interleukin-1 - pharmacology Medical sciences Molecular Sequence Data Monocytes - drug effects Monocytes - metabolism Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	Sixty-five natural flavonoids of various chemical classes were screened for their ability to inhibit the procoagulant activity of adherent human monocytes stimulated by endotoxin and interleukin-1β in vitro. Eighteen of these compounds inhibited the interleukin-1β-induced expression of tissue factor on human monocytes, but the most active compound was a biflavonoid: hinokiflavone.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np960057s