Down-regulation of rat β-adrenoceptors by clenbuterol or desipramine does not require chronic treatment: [ 3H]CGP-12177 binding reveals rapid (24 hour) modulation

Down-regulation of rat β-adrenoceptors by clenbuterol or desipramine does not require chronic treatment: [ 3H]CGP-12177 binding reveals rapid (24 hour) modulation

Desipramine (DMI, 15 mg/kg, s.c.) decreased [ 3H]CGP-12177-labelled cortical β-adrenoceptor density (B max) by 30% upon chronic (14 day) treatment. However, even a single dose (in mg/kg) of DMI (15) or the β-adrenoceptor agonist, clenbuterol (20), induced a rapid (24 hour) and significant reduction...

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Veröffentlicht in:Brain research bulletin 1996, Vol.41 (2), p.93-96
Hauptverfasser: Newman-Tancredi, A., Verrièle, L., Chaput, C., Millan, M.J.
Format: Artikel
Sprache:eng
Schlagworte:
[ 3H]CGP-12177
Acute treatment
Adrenergic beta-Agonists - pharmacology
Adrenergic beta-Antagonists - pharmacokinetics
Adrenergic Uptake Inhibitors - pharmacology
Animals
Antidepressive Agents, Second-Generation - pharmacology
Biological and medical sciences
Clenbuterol
Clenbuterol - pharmacology
Desipramine
Desipramine - pharmacology
Down-regulation
Down-Regulation - drug effects
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Propanolamines - pharmacokinetics
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Wistar
Receptors, Adrenergic, beta - biosynthesis
Receptors, Adrenergic, beta - drug effects
Receptors, Serotonin - biosynthesis
Receptors, Serotonin - drug effects
β-Adrenoceptor
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Zusammenfassung:Desipramine (DMI, 15 mg/kg, s.c.) decreased [ 3H]CGP-12177-labelled cortical β-adrenoceptor density (B max) by 30% upon chronic (14 day) treatment. However, even a single dose (in mg/kg) of DMI (15) or the β-adrenoceptor agonist, clenbuterol (20), induced a rapid (24 hour) and significant reduction of β-adrenoceptor B max (−15%; p
ISSN:0361-9230
1873-2747
DOI:10.1016/0361-9230(96)00150-5