Hepatitis A vaccine responses in HIV-positive persons with haemophilia
The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia and healthy male controls. The vaccine was well tolerated. Seroconversion occurred among all controls after one dose of vaccine but was de...
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| Veröffentlicht in: | Vaccine 1996-08, Vol.14 (11), p.1039-1041 |
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| creator | Tilzey, Anthea J. Palmer, Sara J. Harrington, Chris O'Doherty, Michael J. |
| description | The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia and healthy male controls. The vaccine was well tolerated. Seroconversion occurred among all controls after one dose of vaccine but was delayed among patients, particularly if HIV-positive—4 of 17 (24%) failed to respond to three doses of vaccine. Following the third dose of vaccine, geometric mean titres were significantly higher among controls (1354) than among HIV infected patients (204) (
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| doi_str_mv | 10.1016/0264-410X(96)00056-4 |
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P<0.05). Non-responders failed to develop an immune response following boosting with high titre vaccine. Patients with haemophilia may be vaccinated against HA s.c. but consideration should be given to ensuring that HIV-positive individuals with haemophilia and other immunosuppressed individuals should have their immune responses checked since additional booster doses or passive prophylaxis may be necessary in such individuals.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/0264-410X(96)00056-4</identifier><identifier>PMID: 8879099</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; AIDS/HIV ; Biological and medical sciences ; Hematologic and hematopoietic diseases ; Hemophilia A - immunology ; Hepatitis A Antibodies ; Hepatitis A vaccine ; Hepatitis A Vaccines ; hepatitis A virus ; Hepatitis Antibodies - biosynthesis ; HIV Infections - immunology ; HIV positive individuals with haemophilia ; human immunodeficiency virus ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Injections, Subcutaneous ; Male ; Medical sciences ; Middle Aged ; Other diseases. Hematologic involvement in other diseases ; subcutaneous route ; Vaccines, Inactivated - immunology ; Viral Hepatitis Vaccines - administration & dosage ; Viral Hepatitis Vaccines - adverse effects ; Viral Hepatitis Vaccines - immunology</subject><ispartof>Vaccine, 1996-08, Vol.14 (11), p.1039-1041</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e059215b2902146d8ecfb069efdfec5a4bc05ea5975afe4d2bd3a4c0fdccc6e33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0264-410X(96)00056-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3201578$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8879099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tilzey, Anthea J.</creatorcontrib><creatorcontrib>Palmer, Sara J.</creatorcontrib><creatorcontrib>Harrington, Chris</creatorcontrib><creatorcontrib>O'Doherty, Michael J.</creatorcontrib><title>Hepatitis A vaccine responses in HIV-positive persons with haemophilia</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia and healthy male controls. The vaccine was well tolerated. Seroconversion occurred among all controls after one dose of vaccine but was delayed among patients, particularly if HIV-positive—4 of 17 (24%) failed to respond to three doses of vaccine. Following the third dose of vaccine, geometric mean titres were significantly higher among controls (1354) than among HIV infected patients (204) (
P<0.05). Non-responders failed to develop an immune response following boosting with high titre vaccine. Patients with haemophilia may be vaccinated against HA s.c. but consideration should be given to ensuring that HIV-positive individuals with haemophilia and other immunosuppressed individuals should have their immune responses checked since additional booster doses or passive prophylaxis may be necessary in such individuals.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemophilia A - immunology</subject><subject>Hepatitis A Antibodies</subject><subject>Hepatitis A vaccine</subject><subject>Hepatitis A Vaccines</subject><subject>hepatitis A virus</subject><subject>Hepatitis Antibodies - biosynthesis</subject><subject>HIV Infections - immunology</subject><subject>HIV positive individuals with haemophilia</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>subcutaneous route</subject><subject>Vaccines, Inactivated - immunology</subject><subject>Viral Hepatitis Vaccines - administration & dosage</subject><subject>Viral Hepatitis Vaccines - adverse effects</subject><subject>Viral Hepatitis Vaccines - immunology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRtH78A4UcRPQQ3U12k-xFKGJtQfCi4m3ZTCZ0JU3iTlrx35vQ0KOehuF93mF4GDsX_FZwkdzxKJGhFPzjWic3nHOVhHKPTUSWxmGkRLbPJjvkiB0TfQ5QLPQhO8yyVHOtJ2w2x9Z2rnMUTIONBXA1Bh6pbWpCClwdzBfvYdtQj2wwaNFTnwTfrlsGS4urpl26ytlTdlDaivBsnCfsbfb4-jAPn1-eFg_T5xCkSLsQudKRUHmkeSRkUmQIZc4TjWVRIigrc-AKrdKpsiXKIsqL2ErgZQEACcbxCbva3m1987VG6szKEWBV2RqbNZk0k1JrLv4FhcqETtKoB-UWBN8QeSxN693K-h8juBk8m0GiGSQa3S-DZyP72sV4f52vsNiVRrF9fjnmlsBWpbc1ONphccSFSrMeu99i2EvbOPSGwGENWDiP0JmicX__8QvMXJov</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Tilzey, Anthea J.</creator><creator>Palmer, Sara J.</creator><creator>Harrington, Chris</creator><creator>O'Doherty, Michael J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19960801</creationdate><title>Hepatitis A vaccine responses in HIV-positive persons with haemophilia</title><author>Tilzey, Anthea J. ; Palmer, Sara J. ; Harrington, Chris ; O'Doherty, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e059215b2902146d8ecfb069efdfec5a4bc05ea5975afe4d2bd3a4c0fdccc6e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemophilia A - immunology</topic><topic>Hepatitis A Antibodies</topic><topic>Hepatitis A vaccine</topic><topic>Hepatitis A Vaccines</topic><topic>hepatitis A virus</topic><topic>Hepatitis Antibodies - biosynthesis</topic><topic>HIV Infections - immunology</topic><topic>HIV positive individuals with haemophilia</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>subcutaneous route</topic><topic>Vaccines, Inactivated - immunology</topic><topic>Viral Hepatitis Vaccines - administration & dosage</topic><topic>Viral Hepatitis Vaccines - adverse effects</topic><topic>Viral Hepatitis Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tilzey, Anthea J.</creatorcontrib><creatorcontrib>Palmer, Sara J.</creatorcontrib><creatorcontrib>Harrington, Chris</creatorcontrib><creatorcontrib>O'Doherty, Michael J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tilzey, Anthea J.</au><au>Palmer, Sara J.</au><au>Harrington, Chris</au><au>O'Doherty, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis A vaccine responses in HIV-positive persons with haemophilia</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>14</volume><issue>11</issue><spage>1039</spage><epage>1041</epage><pages>1039-1041</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia and healthy male controls. The vaccine was well tolerated. Seroconversion occurred among all controls after one dose of vaccine but was delayed among patients, particularly if HIV-positive—4 of 17 (24%) failed to respond to three doses of vaccine. Following the third dose of vaccine, geometric mean titres were significantly higher among controls (1354) than among HIV infected patients (204) (
P<0.05). Non-responders failed to develop an immune response following boosting with high titre vaccine. Patients with haemophilia may be vaccinated against HA s.c. but consideration should be given to ensuring that HIV-positive individuals with haemophilia and other immunosuppressed individuals should have their immune responses checked since additional booster doses or passive prophylaxis may be necessary in such individuals.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8879099</pmid><doi>10.1016/0264-410X(96)00056-4</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Aged AIDS/HIV Biological and medical sciences Hematologic and hematopoietic diseases Hemophilia A - immunology Hepatitis A Antibodies Hepatitis A vaccine Hepatitis A Vaccines hepatitis A virus Hepatitis Antibodies - biosynthesis HIV Infections - immunology HIV positive individuals with haemophilia human immunodeficiency virus Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Injections, Subcutaneous Male Medical sciences Middle Aged Other diseases. Hematologic involvement in other diseases subcutaneous route Vaccines, Inactivated - immunology Viral Hepatitis Vaccines - administration & dosage Viral Hepatitis Vaccines - adverse effects Viral Hepatitis Vaccines - immunology |
| title | Hepatitis A vaccine responses in HIV-positive persons with haemophilia |
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