Hepatitis A vaccine responses in HIV-positive persons with haemophilia

Hepatitis A vaccine responses in HIV-positive persons with haemophilia

The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia and healthy male controls. The vaccine was well tolerated. Seroconversion occurred among all controls after one dose of vaccine but was de...

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Veröffentlicht in:Vaccine 1996-08, Vol.14 (11), p.1039-1041
Hauptverfasser: Tilzey, Anthea J., Palmer, Sara J., Harrington, Chris, O'Doherty, Michael J.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
AIDS/HIV
Biological and medical sciences
Hematologic and hematopoietic diseases
Hemophilia A - immunology
Hepatitis A Antibodies
Hepatitis A vaccine
Hepatitis A Vaccines
hepatitis A virus
Hepatitis Antibodies - biosynthesis
HIV Infections - immunology
HIV positive individuals with haemophilia
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Injections, Subcutaneous
Male
Medical sciences
Middle Aged
Other diseases. Hematologic involvement in other diseases
subcutaneous route
Vaccines, Inactivated - immunology
Viral Hepatitis Vaccines - administration & dosage
Viral Hepatitis Vaccines - adverse effects
Viral Hepatitis Vaccines - immunology
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Zusammenfassung:The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia and healthy male controls. The vaccine was well tolerated. Seroconversion occurred among all controls after one dose of vaccine but was delayed among patients, particularly if HIV-positive—4 of 17 (24%) failed to respond to three doses of vaccine. Following the third dose of vaccine, geometric mean titres were significantly higher among controls (1354) than among HIV infected patients (204) ( P
ISSN:0264-410X
1873-2518
DOI:10.1016/0264-410X(96)00056-4