Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1
Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified. 1 In most families affected with t...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 1996-11, Vol.335 (19), p.1413-1416 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1416 |
|---|---|
| container_issue | 19 |
| container_start_page | 1413 |
| container_title | The New England journal of medicine |
| container_volume | 335 |
| creator | Rubin, Stephen C Benjamin, Ivor Behbakht, Kian Takahashi, Hiroyuki Morgan, Mark A LiVolsi, Virginia A Berchuck, Andrew Muto, Michael G Garber, Judy E Weber, Barbara L Lynch, Henry T Boyd, Jeff |
| description | Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified.
1
In most families affected with the breast-and-ovarian-cancer syndrome or site-specific ovarian cancer, genetic linkage has been found to the
BRCA1
locus on chromosome 17q21.
2
,
3
Allelic deletion at the
BRCA1
locus in tumors from these linked family members invariably involves the wild-type chromosome, suggesting that
BRCA1
functions as a tumor-suppressor gene.
4
The cloning of
BRCA1
5
has allowed direct identification of . . . |
| doi_str_mv | 10.1056/NEJM199611073351901 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78449843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78449843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-49a405cfdfd75a9b32b98a0baecef698d9c462579ed795823d3710ec3a4c2c473</originalsourceid><addsrcrecordid>eNqFkV9rFDEUxYModVv9BCIEEV9kNH8nyWMd2qpsrYjiY8hm7tgsM0mbzFj89qbdpQ8impcLub9zbnIPQs8oeUOJbN9-Ovl4To1pKSWKc0kNoQ_QikrOGyFI-xCtCGG6Ecrwx-iwlC2phwpzgA60VtJQtUK2G0MM3o3YxR5_dvNlGtOPu4tTcPOSoeA04IufLgcXceeih4xDxN_TBBHfhPkSn0GemnWIgM-X2c0hxTvNuy_dMX2CHg1uLPB0X4_Qt9OTr937Zn1x9qE7Xjde0nZuhHGCSD_0Q6-kMxvONkY7snHgYWiN7o0XLZPKQK-M1Iz3XFECnjvhmReKH6FXO9-rnK4XKLOdQvEwji5CWopVWgijBf8vSKU2TMhbxxd_gNu05Fg_YRnjRpFWkgrxHeRzKiXDYK9ymFz-ZSmxtyHZv4RUVc_31stmgv5es0-l9l_u-67UJIZctx7KPcaElvWNFXu9w6ap2Ajb6Z9DfwPUf6OW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223970650</pqid></control><display><type>article</type><title>Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>New England Journal of Medicine</source><creator>Rubin, Stephen C ; Benjamin, Ivor ; Behbakht, Kian ; Takahashi, Hiroyuki ; Morgan, Mark A ; LiVolsi, Virginia A ; Berchuck, Andrew ; Muto, Michael G ; Garber, Judy E ; Weber, Barbara L ; Lynch, Henry T ; Boyd, Jeff</creator><creatorcontrib>Rubin, Stephen C ; Benjamin, Ivor ; Behbakht, Kian ; Takahashi, Hiroyuki ; Morgan, Mark A ; LiVolsi, Virginia A ; Berchuck, Andrew ; Muto, Michael G ; Garber, Judy E ; Weber, Barbara L ; Lynch, Henry T ; Boyd, Jeff</creatorcontrib><description>Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified.
1
In most families affected with the breast-and-ovarian-cancer syndrome or site-specific ovarian cancer, genetic linkage has been found to the
BRCA1
locus on chromosome 17q21.
2
,
3
Allelic deletion at the
BRCA1
locus in tumors from these linked family members invariably involves the wild-type chromosome, suggesting that
BRCA1
functions as a tumor-suppressor gene.
4
The cloning of
BRCA1
5
has allowed direct identification of . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199611073351901</identifier><identifier>PMID: 8875917</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Actuarial Analysis ; Adenocarcinoma - genetics ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Age of Onset ; Aged ; Biological and medical sciences ; Case-Control Studies ; Colleges & universities ; Female ; Female genital diseases ; Follow-Up Studies ; Genes ; Genes, BRCA1 ; Genetics ; Germ-Line Mutation ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Mutation ; Neoplasm Staging ; Ovarian cancer ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Survival Analysis ; Tumors</subject><ispartof>The New England journal of medicine, 1996-11, Vol.335 (19), p.1413-1416</ispartof><rights>Copyright © 1996 Massachusetts Medical Society. All rights reserved.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-49a405cfdfd75a9b32b98a0baecef698d9c462579ed795823d3710ec3a4c2c473</citedby><cites>FETCH-LOGICAL-c516t-49a405cfdfd75a9b32b98a0baecef698d9c462579ed795823d3710ec3a4c2c473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199611073351901$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199611073351901$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2485924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8875917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rubin, Stephen C</creatorcontrib><creatorcontrib>Benjamin, Ivor</creatorcontrib><creatorcontrib>Behbakht, Kian</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki</creatorcontrib><creatorcontrib>Morgan, Mark A</creatorcontrib><creatorcontrib>LiVolsi, Virginia A</creatorcontrib><creatorcontrib>Berchuck, Andrew</creatorcontrib><creatorcontrib>Muto, Michael G</creatorcontrib><creatorcontrib>Garber, Judy E</creatorcontrib><creatorcontrib>Weber, Barbara L</creatorcontrib><creatorcontrib>Lynch, Henry T</creatorcontrib><creatorcontrib>Boyd, Jeff</creatorcontrib><title>Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified.
1
In most families affected with the breast-and-ovarian-cancer syndrome or site-specific ovarian cancer, genetic linkage has been found to the
BRCA1
locus on chromosome 17q21.
2
,
3
Allelic deletion at the
BRCA1
locus in tumors from these linked family members invariably involves the wild-type chromosome, suggesting that
BRCA1
functions as a tumor-suppressor gene.
4
The cloning of
BRCA1
5
has allowed direct identification of . . .</description><subject>Actuarial Analysis</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Colleges & universities</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follow-Up Studies</subject><subject>Genes</subject><subject>Genes, BRCA1</subject><subject>Genetics</subject><subject>Germ-Line Mutation</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Staging</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV9rFDEUxYModVv9BCIEEV9kNH8nyWMd2qpsrYjiY8hm7tgsM0mbzFj89qbdpQ8impcLub9zbnIPQs8oeUOJbN9-Ovl4To1pKSWKc0kNoQ_QikrOGyFI-xCtCGG6Ecrwx-iwlC2phwpzgA60VtJQtUK2G0MM3o3YxR5_dvNlGtOPu4tTcPOSoeA04IufLgcXceeih4xDxN_TBBHfhPkSn0GemnWIgM-X2c0hxTvNuy_dMX2CHg1uLPB0X4_Qt9OTr937Zn1x9qE7Xjde0nZuhHGCSD_0Q6-kMxvONkY7snHgYWiN7o0XLZPKQK-M1Iz3XFECnjvhmReKH6FXO9-rnK4XKLOdQvEwji5CWopVWgijBf8vSKU2TMhbxxd_gNu05Fg_YRnjRpFWkgrxHeRzKiXDYK9ymFz-ZSmxtyHZv4RUVc_31stmgv5es0-l9l_u-67UJIZctx7KPcaElvWNFXu9w6ap2Ajb6Z9DfwPUf6OW</recordid><startdate>19961107</startdate><enddate>19961107</enddate><creator>Rubin, Stephen C</creator><creator>Benjamin, Ivor</creator><creator>Behbakht, Kian</creator><creator>Takahashi, Hiroyuki</creator><creator>Morgan, Mark A</creator><creator>LiVolsi, Virginia A</creator><creator>Berchuck, Andrew</creator><creator>Muto, Michael G</creator><creator>Garber, Judy E</creator><creator>Weber, Barbara L</creator><creator>Lynch, Henry T</creator><creator>Boyd, Jeff</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19961107</creationdate><title>Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1</title><author>Rubin, Stephen C ; Benjamin, Ivor ; Behbakht, Kian ; Takahashi, Hiroyuki ; Morgan, Mark A ; LiVolsi, Virginia A ; Berchuck, Andrew ; Muto, Michael G ; Garber, Judy E ; Weber, Barbara L ; Lynch, Henry T ; Boyd, Jeff</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-49a405cfdfd75a9b32b98a0baecef698d9c462579ed795823d3710ec3a4c2c473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Actuarial Analysis</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Colleges & universities</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follow-Up Studies</topic><topic>Genes</topic><topic>Genes, BRCA1</topic><topic>Genetics</topic><topic>Germ-Line Mutation</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasm Staging</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rubin, Stephen C</creatorcontrib><creatorcontrib>Benjamin, Ivor</creatorcontrib><creatorcontrib>Behbakht, Kian</creatorcontrib><creatorcontrib>Takahashi, Hiroyuki</creatorcontrib><creatorcontrib>Morgan, Mark A</creatorcontrib><creatorcontrib>LiVolsi, Virginia A</creatorcontrib><creatorcontrib>Berchuck, Andrew</creatorcontrib><creatorcontrib>Muto, Michael G</creatorcontrib><creatorcontrib>Garber, Judy E</creatorcontrib><creatorcontrib>Weber, Barbara L</creatorcontrib><creatorcontrib>Lynch, Henry T</creatorcontrib><creatorcontrib>Boyd, Jeff</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rubin, Stephen C</au><au>Benjamin, Ivor</au><au>Behbakht, Kian</au><au>Takahashi, Hiroyuki</au><au>Morgan, Mark A</au><au>LiVolsi, Virginia A</au><au>Berchuck, Andrew</au><au>Muto, Michael G</au><au>Garber, Judy E</au><au>Weber, Barbara L</au><au>Lynch, Henry T</au><au>Boyd, Jeff</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1996-11-07</date><risdate>1996</risdate><volume>335</volume><issue>19</issue><spage>1413</spage><epage>1416</epage><pages>1413-1416</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified.
1
In most families affected with the breast-and-ovarian-cancer syndrome or site-specific ovarian cancer, genetic linkage has been found to the
BRCA1
locus on chromosome 17q21.
2
,
3
Allelic deletion at the
BRCA1
locus in tumors from these linked family members invariably involves the wild-type chromosome, suggesting that
BRCA1
functions as a tumor-suppressor gene.
4
The cloning of
BRCA1
5
has allowed direct identification of . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>8875917</pmid><doi>10.1056/NEJM199611073351901</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1996-11, Vol.335 (19), p.1413-1416 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78449843 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Actuarial Analysis Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Age of Onset Aged Biological and medical sciences Case-Control Studies Colleges & universities Female Female genital diseases Follow-Up Studies Genes Genes, BRCA1 Genetics Germ-Line Mutation Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Mutation Neoplasm Staging Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Survival Analysis Tumors |
| title | Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T20%3A36%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20and%20Pathological%20Features%20of%20Ovarian%20Cancer%20in%20Women%20with%20Germ-Line%20Mutations%20of%20BRCA1&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Rubin,%20Stephen%20C&rft.date=1996-11-07&rft.volume=335&rft.issue=19&rft.spage=1413&rft.epage=1416&rft.pages=1413-1416&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJM199611073351901&rft_dat=%3Cproquest_cross%3E78449843%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223970650&rft_id=info:pmid/8875917&rfr_iscdi=true |