Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1
Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified. 1 In most families affected with t...
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Veröffentlicht in: | The New England journal of medicine 1996-11, Vol.335 (19), p.1413-1416 |
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Sprache: | eng |
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Zusammenfassung: | Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified.
1
In most families affected with the breast-and-ovarian-cancer syndrome or site-specific ovarian cancer, genetic linkage has been found to the
BRCA1
locus on chromosome 17q21.
2
,
3
Allelic deletion at the
BRCA1
locus in tumors from these linked family members invariably involves the wild-type chromosome, suggesting that
BRCA1
functions as a tumor-suppressor gene.
4
The cloning of
BRCA1
5
has allowed direct identification of . . . |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJM199611073351901 |