Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of BRCA1

Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified. 1 In most families affected with t...

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Veröffentlicht in:The New England journal of medicine 1996-11, Vol.335 (19), p.1413-1416
Hauptverfasser: Rubin, Stephen C, Benjamin, Ivor, Behbakht, Kian, Takahashi, Hiroyuki, Morgan, Mark A, LiVolsi, Virginia A, Berchuck, Andrew, Muto, Michael G, Garber, Judy E, Weber, Barbara L, Lynch, Henry T, Boyd, Jeff
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Sprache:eng
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Zusammenfassung:Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been identified. 1 In most families affected with the breast-and-ovarian-cancer syndrome or site-specific ovarian cancer, genetic linkage has been found to the BRCA1 locus on chromosome 17q21. 2 , 3 Allelic deletion at the BRCA1 locus in tumors from these linked family members invariably involves the wild-type chromosome, suggesting that BRCA1 functions as a tumor-suppressor gene. 4 The cloning of BRCA1 5 has allowed direct identification of . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199611073351901