Nontoxic concentration of amphotericin B for intravitreal use-evaluated by in vitro ERG
Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly...
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| Veröffentlicht in: | Documenta ophthalmologica 1988-05, Vol.69 (1), p.19-23 |
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| container_title | Documenta ophthalmologica |
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| creator | KAWASAKI, K OHNOGI, J OKAYAMA, Y |
| description | Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly reversible. The b-wave and oscillatory potentials were greatly suppressed by 50 microM AMPH. These changes were only partially reversible 75 minutes after re-perfusion without AMPH. |
| doi_str_mv | 10.1007/BF00154415 |
| format | Article |
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The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly reversible. The b-wave and oscillatory potentials were greatly suppressed by 50 microM AMPH. These changes were only partially reversible 75 minutes after re-perfusion without AMPH.</description><identifier>ISSN: 0012-4486</identifier><identifier>EISSN: 1573-2622</identifier><identifier>DOI: 10.1007/BF00154415</identifier><identifier>PMID: 3168708</identifier><identifier>CODEN: DOOPAA</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Amphotericin B - administration & dosage ; Amphotericin B - pharmacology ; Animals ; Biological and medical sciences ; Electroretinography ; Eye ; In Vitro Techniques ; Injections ; Medical sciences ; Osmolar Concentration ; Perfusion ; Pharmacology. 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Drug treatments</subject><subject>Rabbits</subject><subject>Retina - drug effects</subject><subject>Vitreous Body</subject><issn>0012-4486</issn><issn>1573-2622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLwzAYhoMoc04v3oUcxINQTdKkSY5ubFMYCqJ4LGmaYKRrZpIO9-_tsMz38sH3PLyHF4BLjO4wQvx-ukAIM0oxOwJjzHiekYKQYzDu3ySjVBSn4CzGL4SQ5FiMwCjHheBIjMHHs2-T_3Eaat9q06agkvMt9Baq9ebTJxOcdi2cQusDdHu-dSkY1cAumsxsVdOpZGpY7XoK98zD-evyHJxY1URzMdwJeF_M32aP2epl-TR7WGWakCJlREuh60JrYlXFqRQs78MKYw3NseQc61pIpbhghDBpkeaIcl4QyRWqGMkn4OavdxP8d2diKtcuatM0qjW-iyUXtI9kvXj7J-rgYwzGlpvg1irsSozK_Yrl_4q9fDW0dtXa1Ad1mK3n1wNXUavGBtVqFw8a5znlhcx_AQtkeDE</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>KAWASAKI, K</creator><creator>OHNOGI, J</creator><creator>OKAYAMA, Y</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198805</creationdate><title>Nontoxic concentration of amphotericin B for intravitreal use-evaluated by in vitro ERG</title><author>KAWASAKI, K ; OHNOGI, J ; OKAYAMA, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-2c98cd6cc2fab74985333356efe4319771cd89aa7852259f0c704776297a0b523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amphotericin B - administration & dosage</topic><topic>Amphotericin B - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electroretinography</topic><topic>Eye</topic><topic>In Vitro Techniques</topic><topic>Injections</topic><topic>Medical sciences</topic><topic>Osmolar Concentration</topic><topic>Perfusion</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Retina - drug effects</topic><topic>Vitreous Body</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWASAKI, K</creatorcontrib><creatorcontrib>OHNOGI, J</creatorcontrib><creatorcontrib>OKAYAMA, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Documenta ophthalmologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAWASAKI, K</au><au>OHNOGI, J</au><au>OKAYAMA, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nontoxic concentration of amphotericin B for intravitreal use-evaluated by in vitro ERG</atitle><jtitle>Documenta ophthalmologica</jtitle><addtitle>Doc Ophthalmol</addtitle><date>1988-05</date><risdate>1988</risdate><volume>69</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0012-4486</issn><eissn>1573-2622</eissn><coden>DOOPAA</coden><abstract>Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. 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| fulltext | fulltext |
| identifier | ISSN: 0012-4486 |
| ispartof | Documenta ophthalmologica, 1988-05, Vol.69 (1), p.19-23 |
| issn | 0012-4486 1573-2622 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78444495 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Amphotericin B - administration & dosage Amphotericin B - pharmacology Animals Biological and medical sciences Electroretinography Eye In Vitro Techniques Injections Medical sciences Osmolar Concentration Perfusion Pharmacology. Drug treatments Rabbits Retina - drug effects Vitreous Body |
| title | Nontoxic concentration of amphotericin B for intravitreal use-evaluated by in vitro ERG |
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