Nontoxic concentration of amphotericin B for intravitreal use-evaluated by in vitro ERG

Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly...

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Veröffentlicht in:	Documenta ophthalmologica 1988-05, Vol.69 (1), p.19-23
Hauptverfasser:	KAWASAKI, K, OHNOGI, J, OKAYAMA, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - administration & dosage Amphotericin B - pharmacology Animals Biological and medical sciences Electroretinography Eye In Vitro Techniques Injections Medical sciences Osmolar Concentration Perfusion Pharmacology. Drug treatments Rabbits Retina - drug effects Vitreous Body
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Zusammenfassung:	Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 microM AMPH, and these all were slightly suppressed by 5 microM AMPH. These changes were mostly reversible. The b-wave and oscillatory potentials were greatly suppressed by 50 microM AMPH. These changes were only partially reversible 75 minutes after re-perfusion without AMPH.
ISSN:	0012-4486 1573-2622
DOI:	10.1007/BF00154415