Widespread ectopic neuropeptide-Y immunoreactivity in contralateral mossy fibres after a unilateral intrahippocampal kainic acid injection in the rat

Granule cells of the dentate gyrus can express neuropeptide-Y (NPY) in several models of epilepsy involving limbic seizures, however, the nature of this ectopic expression is not well understood at present. We have studied the expression of NPY-immunoreactivity in mossy fibres contralateral to a uni...

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Veröffentlicht in:	Neuroscience letters 1996-08, Vol.213 (3), p.181-184
Hauptverfasser:	Lurton, D., Coussemacq, M., Barrow, P., Sundstrom, L.E., Rougier, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity Biological and medical sciences Epilepsy Epilepsy - physiopathology Excitatory Amino Acid Agonists - pharmacology Granule cells Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - chemistry Hippocampus - cytology Hippocampus - drug effects Immunohistochemistry Kainic acid Kainic Acid - pharmacology Male Medical sciences Microinjections Nervous system (semeiology, syndromes) Neurology Neuropeptide Y - analysis Neuropeptide Y - immunology Neuropeptide-Y Rats Rats, Wistar Seizures
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Zusammenfassung:	Granule cells of the dentate gyrus can express neuropeptide-Y (NPY) in several models of epilepsy involving limbic seizures, however, the nature of this ectopic expression is not well understood at present. We have studied the expression of NPY-immunoreactivity in mossy fibres contralateral to a unilateral intrahippocampal injection of kainic acid and report that ectopic mossy fibre NPY-immunoreactivity is observed throughout the contralateral hippocampus.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(96)12854-8