Glioblastoma multiforme masquerading as a pleomorphic xanthoastrocytoma

Since its first description by Kepes in 1979, pleomorphic xanthoastrocytoma (PXA) has been considered a tumor with a benign course. Two cases are presented here that support the concept that PXA may be more accurately considered part of a spectrum of astrocytomas that occasionally may act aggressive...

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Veröffentlicht in:Child's nervous system 1988-08, Vol.4 (4), p.237-240
Hauptverfasser: Gaskill, S J, Marlin, A E, Saldivar, V
Format: Artikel
Sprache:eng
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Zusammenfassung:Since its first description by Kepes in 1979, pleomorphic xanthoastrocytoma (PXA) has been considered a tumor with a benign course. Two cases are presented here that support the concept that PXA may be more accurately considered part of a spectrum of astrocytomas that occasionally may act aggressively. These cases represent astrocytomas with PXA components and are characterized by meningeal proximity, a high number of mitoses, and subsequently aggressive clinical behavior. The importance of recognizing the potential of a "benign" PXA to transform into a malignant entity has obvious implications for the therapeutic management of these tumors.
ISSN:0256-7040
1433-0350
DOI:10.1007/BF00270921