Release of a virus coded glycoprotein from herpes simplex virus type 1 infected cells

HEp-2 cells, which were infected with HSV-1, excrete besides other proteins a soluble glycoprotein (Mr 125,000-130,000) related to the virus protein gC. The excretion of the glycoprotein and the production of extracellular virus particles is reduced to a similar extent when the cells were treated wi...

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Veröffentlicht in:	Molecular biology reports 1988-01, Vol.13 (1), p.29-33
Hauptverfasser:	TIEDEMANN, K.-H, HAMPL, H, HABERMEHL, K. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cells, Cultured Fundamental and applied biological sciences. Psychology Glycoproteins - genetics Glycoproteins - metabolism Humans Microbiology Monensin - pharmacology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Simplexvirus - genetics Virology
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Zusammenfassung:	HEp-2 cells, which were infected with HSV-1, excrete besides other proteins a soluble glycoprotein (Mr 125,000-130,000) related to the virus protein gC. The excretion of the glycoprotein and the production of extracellular virus particles is reduced to a similar extent when the cells were treated with monensin. Possible consequences of the excretion of soluble viral proteins to a modulation of the immune response are discussed.
ISSN:	0301-4851 1573-4978
DOI:	10.1007/BF00805636