A new role for CD23 in inflammation

CD23, is expressed on a variety of haematopoietic cell types and displays pleiotropic activities in vitro. Here Jean-Yves Bonnefoy and collegues discuss a novel interaction between CD23 and the α chains of the β 2 integrins, CD11b and CD11c, that leads to a proinflammatory pattern of macrophage acti...

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Veröffentlicht in:	Immunology today (Amsterdam. Regular ed.) 1996-09, Vol.17 (9), p.418-420
Hauptverfasser:	Bonnefoy, Jean-Yves, Plater-Zyberk, Christine, Lecoanet-Henchoz, Sybille, Gauchat, Jean-Francois, Aubry, Jean-Pierre, Graber, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Animals Antibodies, Monoclonal - immunology Arthritis - immunology Arthritis - pathology Binding, Competitive - immunology Humans Inflammation - immunology Integrin alphaXbeta2 - metabolism Macrophage Activation - immunology Macrophage-1 Antigen - metabolism Macrophages - immunology Macrophages - metabolism Mice Protein Binding - physiology Receptors, IgE - biosynthesis Receptors, IgE - immunology Receptors, IgE - metabolism
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Beschreibung
Zusammenfassung:	CD23, is expressed on a variety of haematopoietic cell types and displays pleiotropic activities in vitro. Here Jean-Yves Bonnefoy and collegues discuss a novel interaction between CD23 and the α chains of the β 2 integrins, CD11b and CD11c, that leads to a proinflammatory pattern of macrophage activation. They describe how neutralizing antibodies to CD23 can decrease the severity of murine arthritis.
ISSN:	0167-5699
DOI:	10.1016/0167-5699(96)10054-2