A Gene Map of the Human Genome

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeas...

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Veröffentlicht in:	Science 1996-10, Vol.274 (5287), p.540-546
Hauptverfasser:	Schuler, G. D., Boguski, M. S., Stewart, E. A., Stein, L. D., Gyapay, G., Rice, K., White, R. E., Rodriguez-Tomé, P., Aggarwal, A., Bajorek, E., Bentolila, S., Birren, B. B., Butler, A., Chiannilkulchai, N., Chu, A., Clee, C., Cowles, S., Day, P. J. R., Dibling, T., Drouot, N., Dunham, I., Duprat, S., East, C., Edwards, C., J.-B. Fan, Fang, N., Fizames, C., Garrett, C., Green, L., Hadley, D., Harris, M., Brady, S., Hicks, A., Holloway, E., Hui, L., Hussain, S., C. Louis-Dit-Sully, Ma, J., MacGilvery, A., Mader, C., Maratukulam, A., Matise, T. C., McKusick, K. B., Mungall, A., Muselet, D., Nusbaum, H. C., Page, D. C., Peck, A., Perkins, S., Piercy, M., Qin, F., Quackenbush, J., Ranby, S., Reif, T., Rozen, S., Sanders, C., She, X., Silva, J., Slonim, D. K., Soderlund, C., W.-L. Sun, Tabar, P., Thangarajah, T., Vega-Czarny, N., Vollrath, D., Voyticky, S., Wilmer, T., Wu, X., Adams, M. D., Aufiray, C., Walter, N. A. R., Brandon, R., Dehejia, A., Goodfellow, P. N., Houlgatte, R., Hudson, J. R., Ide, S. E., Iorio, K. R., Lee, W. Y., Seki, N., Nagase, T., Ishikawa, K., Nomura, N., Phillips, C., Polymeropoulos, M. H., Sandusky, M., Schmitt, K., Berry, R., Swanson, K., Torres, R., Venter, J. C., Sikela, J. M., Weissenbach, J., Myers, R. M., Cox, D. R., James, M. R., Bentley, D., Deloukas, P., Lander, E. S., Hudson, T. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Cell Line Chromosome Mapping Chromosomes Chromosomes, Artificial, Yeast Classical genetics, quantitative genetics, hybrids Computer Communication Networks Consortia Databases, Factual DNA, Complementary - genetics Fundamental and applied biological sciences. Psychology Gene Expression Genes Genetic loci GENETIC MAPPING Genetic Markers Genetics Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genomes Human Human genetics Human genome Human Genome Project HUMAN POPULATIONS Humans Maps (Geography) Medical genetics Multigene Family RNA, Messenger - genetics Sequence Homology, Nucleic Acid Sequence Tagged Sites Transcripts (Written Records)
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Beschreibung
Zusammenfassung:	The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.274.5287.540