Solution conformation of tuftsin

Solution conformation of tuftsin

Conformation of chemically synthesized tetrapeptide tuftsin, an important immunomodulator, with the sequence Thr-Lys-Pro-Arg-OH has been studied in aqueous solution as well as in a number of organic solvents viz. trifluoroethanol (TFE), methanol and dioxane by circular dichroism (CD) spectroscopy wh...

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Veröffentlicht in:International journal of biological macromolecules 1996-08, Vol.19 (2), p.99-102
Hauptverfasser: Siddiqui, Mahtab Z., Sharma, Ashwani K., Kumar, Satish
Format: Artikel
Sprache:eng
Schlagworte:
Circular Dichroism
Circular dichroism spectroscopy
Conformation
Methanol
Protein Conformation
Solutions
Tuftsin - chemistry
Tuftsin, an immunomodulator peptide
Water
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Zusammenfassung:Conformation of chemically synthesized tetrapeptide tuftsin, an important immunomodulator, with the sequence Thr-Lys-Pro-Arg-OH has been studied in aqueous solution as well as in a number of organic solvents viz. trifluoroethanol (TFE), methanol and dioxane by circular dichroism (CD) spectroscopy which reveals preferential occurrence of mixture of random coil and β-turns, that has already been predicted as bioactive conformation of this peptide.
ISSN:0141-8130
1879-0003
DOI:10.1016/0141-8130(96)01108-7