No evidence for association of dopamine D2 receptor variant (Ser 311/Cys311) with major psychosis

We investigated a variant of the dopamine D2 receptor gene (Ser311/Cys311 substitution) in Caucasian patients with schizophrenia (n = 273), delusional disorder (n = 62), bipolar I affective disorder (n = 63), and controls (n = 255). No evidence for association between the receptor variant and any of...

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Veröffentlicht in:	American journal of medical genetics 1996-07, Vol.67 (4), p.415-417
Hauptverfasser:	Sasaki, Tsukasa, Macciardi, Fabio M., Badri, Farideh, Verga, Massimiliano, Meltzer, Herbert Y., Lieberman, Jeffrey, Howard, Alfreda, Bean, Graham, Joffe, Russel T., Hudson, Craig J., Kennedy, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Age of Onset Amino Acid Sequence Biological and medical sciences bipolar affective disorder Bipolar Disorder - genetics Cysteine delusional disorder Delusions - genetics dopamine D2 receptor European Continental Ancestry Group - genetics Female Genetic Variation genetics Humans Male Medical sciences Middle Aged Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - genetics Receptors, Dopamine D2 - genetics Reference Values Schizophrenia Schizophrenia - genetics Serine
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Zusammenfassung:	We investigated a variant of the dopamine D2 receptor gene (Ser311/Cys311 substitution) in Caucasian patients with schizophrenia (n = 273), delusional disorder (n = 62), bipolar I affective disorder (n = 63), and controls (n = 255). No evidence for association between the receptor variant and any of the diseases was found, even when patients with younger age‐of‐onset (
ISSN:	0148-7299 1096-8628
DOI:	10.1002/(SICI)1096-8628(19960726)67:4<415::AID-AJMG18>3.0.CO;2-M