Striatal D-2 dopamine agonist binding sites fluctuate during the rat estrous cycle
Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of...
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Veröffentlicht in: | Life sciences (1973) 1988, Vol.43 (8), p.665-672 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high to low D-2 agonist binding sites from proestrus AM (PAM) to diestrus 1 (D1) and return to OVX value in diestrus 2 (DII). Thus, physiological fluctuations of hormones as occur during the estrous cycle can modulate extrahypothalamic biogenic amine activity, namely striatal DA systems which are not involved in the control of hormone secretion. |
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ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/0024-3205(88)90137-3 |