Striatal D-2 dopamine agonist binding sites fluctuate during the rat estrous cycle

Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of...

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Veröffentlicht in:Life sciences (1973) 1988, Vol.43 (8), p.665-672
Hauptverfasser: Di Paolo, Thérèse, Falardeau, Pierre, Morissette, Marc
Format: Artikel
Sprache:eng
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Zusammenfassung:Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high to low D-2 agonist binding sites from proestrus AM (PAM) to diestrus 1 (D1) and return to OVX value in diestrus 2 (DII). Thus, physiological fluctuations of hormones as occur during the estrous cycle can modulate extrahypothalamic biogenic amine activity, namely striatal DA systems which are not involved in the control of hormone secretion.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(88)90137-3