Hepatic tumors with hyperglucagonemia response to treatment with human lymphoblastoid interferon

A 62‐year‐old man had necrolytic migratory erythema in association with hyperglucagonemia and multiple hepatic tumors. A diagnosis of metastatic glucagonoma was made. He was treated with human lymphoblastoid interferon given subcutaneously in the dose of 2.8 to 7.1 × 106 IU/day. This produced a considerable fall in plasma glucagon and resolution of the associated rash. The treatment was continued for 10 weeks over a 4‐month period. Computed tomography demonstrated a reduction in hepatic tumor mass.