YM-24074, a New Peptide Antibiotic: II. Structural Elucidation

YM-24074 (formerly called YL-01869P) is a new antibiotic and type I collagenase inhibitor. The structure of this compound was elucidated by spectroscopic analysis and confirmed by acid degradation to be N-(1"-acetyl-3"-methylbutyl)-2-[2'-[(N-hydroxycarbamoyl)methyl]heptanoyl]hexahydro...

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Veröffentlicht in:	Journal of antibiotics 1996/08/25, Vol.49(8), pp.811-814
Hauptverfasser:	SATO, TSUTOMU, TAKEBAYASHI, YUKIHIRO, TOKUNAGA, TATSUHIRO, OZASA, TERUAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Magnetic Resonance Spectroscopy Medical sciences Molecular Conformation Peptides Pharmacology. Drug treatments Pyridazines - chemistry Streptomyces
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Beschreibung
Zusammenfassung:	YM-24074 (formerly called YL-01869P) is a new antibiotic and type I collagenase inhibitor. The structure of this compound was elucidated by spectroscopic analysis and confirmed by acid degradation to be N-(1"-acetyl-3"-methylbutyl)-2-[2'-[(N-hydroxycarbamoyl)methyl]heptanoyl]hexahydropyridazine-3-carboxamide. The stereochemistry of two of three chiral centers was determined by degradation products to be 3S, 2'R.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.49.811