Effect of bilateral decortication on nerve growth factor content in basal nucleus and neostriatum of adult rat brain

The content of nerve growth factor (NGF) was measured by a sensitive two-site enzyme-linked immunosorbent assay in the basal nucleus and neostriatum at various times following bilateral suction lesions of the cerebral neocortex in adult rats. At 14 and 29 postlesion days, NGF levels in basal nucleus...

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Veröffentlicht in:	Brain research 1988-06, Vol.454 (1), p.355-360
Hauptverfasser:	Lorez, H.P., von Frankenberg, M., Weskamp, G., Otten, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal Ganglia - metabolism Basal nucleus Biological and medical sciences Brain plasticity Cerebral cortex Cerebral Cortex - physiology Corpus Striatum - metabolism Degeneration. Regeneration. Wound healing. Graft Fundamental and applied biological sciences. Psychology Male Neostriatum Nerve Degeneration Nerve growth factor Nerve Growth Factors - metabolism Neural Pathways - metabolism Neural Pathways - physiology Neuronal degeneration Organ Size Rat Rat brain injury Rats Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	The content of nerve growth factor (NGF) was measured by a sensitive two-site enzyme-linked immunosorbent assay in the basal nucleus and neostriatum at various times following bilateral suction lesions of the cerebral neocortex in adult rats. At 14 and 29 postlesion days, NGF levels in basal nucleus were significantly elevated by 270 and 126%, respectively. In addition, 29 days after cortical lesions, NGF content in the neostriatum was increased 145% above controls. Thus, enhanced NGF production occurs in both basal nucleus and neostriatum of adult rats in response to antero- and/or retrograde neuronal degeneration.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(88)90837-2