Blockade of glutamate receptors in CVLM and NTS attenuates airway dilation evoked from parabrachial region
A. M. Motekaitis, I. C. Solomon and M. P. Kaufman Department of Internal Medicine, University of California, Davis 95616, USA. Previous work from our laboratory has shown that stimulation of cell bodies and dendrites in the medial and lateral parabrachial nuclei dilates the airways. The sites partic...
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Veröffentlicht in: | Journal of applied physiology (1985) 1996-07, Vol.81 (1), p.400-407 |
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Sprache: | eng |
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Zusammenfassung: | A. M. Motekaitis, I. C. Solomon and M. P. Kaufman
Department of Internal Medicine, University of California, Davis 95616, USA.
Previous work from our laboratory has shown that stimulation of cell bodies
and dendrites in the medial and lateral parabrachial nuclei dilates the
airways. The sites participating in the pathway mediating this airway
response are not known. Two likely candidates are the caudal ventrolateral
medulla (CVLM) and the nucleus tractus solitarii (NTS). Using
chloralose-anesthetized cats, we assessed the airway dilation evoked from
the parabrachial region before and during bilateral blockade of the NTS or
the CVLM. The airway dilation arising from stimulation of the parabrachial
region was evoked by microinjection of DL-homocysteic acid (25 nl, 100 mM).
Bilateral blockade of the NTS or CVLM, achieved by microinjection of
kynurenic acid (50 nl, 100 mM), reversibly attenuated the airway dilation
in every cat tested. On average, kynurenic acid-induced blockade of the NTS
caused a more complete attenuation of the dilation evoked from the
parabrachial region than did blockade of the CVLM. Bilateral microinjection
of cobalt chloride (50 nl, 50 mM) into the CVLM gave inconclusive results,
attenuating the airway dilation evoked from the parabrachial region in six
cats and potentiating it in three others. We conclude that the CVLM and the
NTS participate in the airway dilation arising from the parabrachial
region. |
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ISSN: | 8750-7587 1522-1601 |
DOI: | 10.1152/jappl.1996.81.1.400 |