HLA typing in chronic type B, D and C hepatitis
Aims: We aimed to test the hypothesis that susceptibility to chronic HBV, HDV or HCV infections or their pathology is influenced by host genetic factors. Methods: The Human Leukocyte Antigens (HLA) (A, B, DR and DQ) were determined by microlym- phocytotoxicity assay in patients with chronic C ( n=11...
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| Veröffentlicht in: | Journal of hepatology 1996-06, Vol.24 (6), p.658-665 |
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| container_title | Journal of hepatology |
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| creator | Zavaglia, Claudio Bortolon, Cristina Ferrioli, Gabriella Rho, Anna Mondazzi, Luca Bottelli, Riccardo Ghessi, Alberto Gelosa, Franco Iamoni, Gianmaria Ideo, Gaetano |
| description | Aims: We aimed to test the hypothesis that susceptibility to chronic HBV, HDV or HCV infections or their pathology is influenced by host genetic factors.
Methods: The Human Leukocyte Antigens (HLA) (A, B, DR and DQ) were determined by microlym- phocytotoxicity assay in patients with chronic C (
n=117), B (
n=97) or D (
n=27) hepatitis and their frequencies were compared with those of 489 healthy controls.
Results: No statistically significant association was found between any HLA antigen and chronic B or D hepatitis. A significantly higher frequency of HLA-B14 was observed in patients with chronic persistent or active C hepatitis (16.7% of 90 versus 5.9% of 489, χ
2=10.9,
pc |
| doi_str_mv | 10.1016/S0168-8278(96)80260-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78373556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168827896802601</els_id><sourcerecordid>78373556</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-6dd4e26d8b2fc9c9a6af5aaa61e7b66a371b0e9991d7aa75869dcc50c6d440de3</originalsourceid><addsrcrecordid>eNqFkEtLw0AQgBdRaq3-hEIOIgrG7maTfZyk1keFggf1vGx2J3YlTepuKvTfm7ShVy8zMPPNgw-hMcF3BBM2eW-DiEXCxbVkNwInDMfkCA0JwzjGLCXHaHhATtFZCN8YY4plOkADIWjGqRyiyXwxjZrt2lVfkasis_R15UxXgejhNnqMdGWjWbSEtW5c48I5Oil0GeCizyP0-fz0MZvHi7eX19l0EZuUiCZm1qaQMCvypDDSSM10kWmtGQGeM6YpJzkGKSWxXGueCSatMRk2zKYptkBH6Gq_d-3rnw2ERq1cMFCWuoJ6ExQXlNMsYy2Y7UHj6xA8FGrt3Ur7rSJYdaLUTpTqLCjJ1E6UIu3cuD-wyVdgD1O9mbZ_2fd1MLosvK6MCweMEkqw6Nbc7zFoZfw68CoYB5UB6zyYRtna_fPIH1hkgpU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78373556</pqid></control><display><type>article</type><title>HLA typing in chronic type B, D and C hepatitis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Zavaglia, Claudio ; Bortolon, Cristina ; Ferrioli, Gabriella ; Rho, Anna ; Mondazzi, Luca ; Bottelli, Riccardo ; Ghessi, Alberto ; Gelosa, Franco ; Iamoni, Gianmaria ; Ideo, Gaetano</creator><creatorcontrib>Zavaglia, Claudio ; Bortolon, Cristina ; Ferrioli, Gabriella ; Rho, Anna ; Mondazzi, Luca ; Bottelli, Riccardo ; Ghessi, Alberto ; Gelosa, Franco ; Iamoni, Gianmaria ; Ideo, Gaetano</creatorcontrib><description>Aims: We aimed to test the hypothesis that susceptibility to chronic HBV, HDV or HCV infections or their pathology is influenced by host genetic factors.
Methods: The Human Leukocyte Antigens (HLA) (A, B, DR and DQ) were determined by microlym- phocytotoxicity assay in patients with chronic C (
n=117), B (
n=97) or D (
n=27) hepatitis and their frequencies were compared with those of 489 healthy controls.
Results: No statistically significant association was found between any HLA antigen and chronic B or D hepatitis. A significantly higher frequency of HLA-B14 was observed in patients with chronic persistent or active C hepatitis (16.7% of 90 versus 5.9% of 489, χ
2=10.9,
pc<0.05, Relative Risk=3.17, Etiological Fraction=0.11). The frequency of HLA-DR5 was lower in HCV positive patients (24.8%) than in controls (45%, χ
2=15.1,
pc<0.005, RR=0.4, EF=−0.37).
Conclusions: No correlation could be observed between clearance of HBV or HDV and HLA phenotype. Immunogenetic factors may have a role in determining susceptibility to chronic HCV hepatitis, and in Italian patients HLA-DR5 is a protective factor.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(96)80260-1</identifier><identifier>PMID: 8835739</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies, Viral - analysis ; Biological and medical sciences ; Biopsy ; Chronic Disease ; Chronic hepatitis ; DNA, Viral - analysis ; Enzyme-Linked Immunosorbent Assay ; Female ; HBV ; HCV ; HDV ; Hepatitis B - immunology ; Hepatitis B - pathology ; Hepatitis B - therapy ; Hepatitis C - immunology ; Hepatitis C - pathology ; Hepatitis C - therapy ; Hepatitis D - immunology ; Hepatitis D - pathology ; Hepatitis D - therapy ; Hepatitis Viruses - genetics ; Hepatitis Viruses - immunology ; Hepatitis Viruses - isolation & purification ; Histocompatibility Testing - methods ; HLA ; HLA Antigens - drug effects ; HLA Antigens - immunology ; Human viral diseases ; Humans ; Immunoblotting ; Immunophenotyping ; Infectious diseases ; Interferons - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Radioimmunoassay ; Retrospective Studies ; Viral diseases ; Viral hepatitis</subject><ispartof>Journal of hepatology, 1996-06, Vol.24 (6), p.658-665</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-6dd4e26d8b2fc9c9a6af5aaa61e7b66a371b0e9991d7aa75869dcc50c6d440de3</citedby><cites>FETCH-LOGICAL-c418t-6dd4e26d8b2fc9c9a6af5aaa61e7b66a371b0e9991d7aa75869dcc50c6d440de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-8278(96)80260-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3131081$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8835739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zavaglia, Claudio</creatorcontrib><creatorcontrib>Bortolon, Cristina</creatorcontrib><creatorcontrib>Ferrioli, Gabriella</creatorcontrib><creatorcontrib>Rho, Anna</creatorcontrib><creatorcontrib>Mondazzi, Luca</creatorcontrib><creatorcontrib>Bottelli, Riccardo</creatorcontrib><creatorcontrib>Ghessi, Alberto</creatorcontrib><creatorcontrib>Gelosa, Franco</creatorcontrib><creatorcontrib>Iamoni, Gianmaria</creatorcontrib><creatorcontrib>Ideo, Gaetano</creatorcontrib><title>HLA typing in chronic type B, D and C hepatitis</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Aims: We aimed to test the hypothesis that susceptibility to chronic HBV, HDV or HCV infections or their pathology is influenced by host genetic factors.
Methods: The Human Leukocyte Antigens (HLA) (A, B, DR and DQ) were determined by microlym- phocytotoxicity assay in patients with chronic C (
n=117), B (
n=97) or D (
n=27) hepatitis and their frequencies were compared with those of 489 healthy controls.
Results: No statistically significant association was found between any HLA antigen and chronic B or D hepatitis. A significantly higher frequency of HLA-B14 was observed in patients with chronic persistent or active C hepatitis (16.7% of 90 versus 5.9% of 489, χ
2=10.9,
pc<0.05, Relative Risk=3.17, Etiological Fraction=0.11). The frequency of HLA-DR5 was lower in HCV positive patients (24.8%) than in controls (45%, χ
2=15.1,
pc<0.005, RR=0.4, EF=−0.37).
Conclusions: No correlation could be observed between clearance of HBV or HDV and HLA phenotype. Immunogenetic factors may have a role in determining susceptibility to chronic HCV hepatitis, and in Italian patients HLA-DR5 is a protective factor.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Chronic Disease</subject><subject>Chronic hepatitis</subject><subject>DNA, Viral - analysis</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>HBV</subject><subject>HCV</subject><subject>HDV</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B - pathology</subject><subject>Hepatitis B - therapy</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - pathology</subject><subject>Hepatitis C - therapy</subject><subject>Hepatitis D - immunology</subject><subject>Hepatitis D - pathology</subject><subject>Hepatitis D - therapy</subject><subject>Hepatitis Viruses - genetics</subject><subject>Hepatitis Viruses - immunology</subject><subject>Hepatitis Viruses - isolation & purification</subject><subject>Histocompatibility Testing - methods</subject><subject>HLA</subject><subject>HLA Antigens - drug effects</subject><subject>HLA Antigens - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunophenotyping</subject><subject>Infectious diseases</subject><subject>Interferons - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radioimmunoassay</subject><subject>Retrospective Studies</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AQgBdRaq3-hEIOIgrG7maTfZyk1keFggf1vGx2J3YlTepuKvTfm7ShVy8zMPPNgw-hMcF3BBM2eW-DiEXCxbVkNwInDMfkCA0JwzjGLCXHaHhATtFZCN8YY4plOkADIWjGqRyiyXwxjZrt2lVfkasis_R15UxXgejhNnqMdGWjWbSEtW5c48I5Oil0GeCizyP0-fz0MZvHi7eX19l0EZuUiCZm1qaQMCvypDDSSM10kWmtGQGeM6YpJzkGKSWxXGueCSatMRk2zKYptkBH6Gq_d-3rnw2ERq1cMFCWuoJ6ExQXlNMsYy2Y7UHj6xA8FGrt3Ur7rSJYdaLUTpTqLCjJ1E6UIu3cuD-wyVdgD1O9mbZ_2fd1MLosvK6MCweMEkqw6Nbc7zFoZfw68CoYB5UB6zyYRtna_fPIH1hkgpU</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Zavaglia, Claudio</creator><creator>Bortolon, Cristina</creator><creator>Ferrioli, Gabriella</creator><creator>Rho, Anna</creator><creator>Mondazzi, Luca</creator><creator>Bottelli, Riccardo</creator><creator>Ghessi, Alberto</creator><creator>Gelosa, Franco</creator><creator>Iamoni, Gianmaria</creator><creator>Ideo, Gaetano</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>HLA typing in chronic type B, D and C hepatitis</title><author>Zavaglia, Claudio ; Bortolon, Cristina ; Ferrioli, Gabriella ; Rho, Anna ; Mondazzi, Luca ; Bottelli, Riccardo ; Ghessi, Alberto ; Gelosa, Franco ; Iamoni, Gianmaria ; Ideo, Gaetano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-6dd4e26d8b2fc9c9a6af5aaa61e7b66a371b0e9991d7aa75869dcc50c6d440de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Chronic Disease</topic><topic>Chronic hepatitis</topic><topic>DNA, Viral - analysis</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>HBV</topic><topic>HCV</topic><topic>HDV</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B - pathology</topic><topic>Hepatitis B - therapy</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C - pathology</topic><topic>Hepatitis C - therapy</topic><topic>Hepatitis D - immunology</topic><topic>Hepatitis D - pathology</topic><topic>Hepatitis D - therapy</topic><topic>Hepatitis Viruses - genetics</topic><topic>Hepatitis Viruses - immunology</topic><topic>Hepatitis Viruses - isolation & purification</topic><topic>Histocompatibility Testing - methods</topic><topic>HLA</topic><topic>HLA Antigens - drug effects</topic><topic>HLA Antigens - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunophenotyping</topic><topic>Infectious diseases</topic><topic>Interferons - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radioimmunoassay</topic><topic>Retrospective Studies</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zavaglia, Claudio</creatorcontrib><creatorcontrib>Bortolon, Cristina</creatorcontrib><creatorcontrib>Ferrioli, Gabriella</creatorcontrib><creatorcontrib>Rho, Anna</creatorcontrib><creatorcontrib>Mondazzi, Luca</creatorcontrib><creatorcontrib>Bottelli, Riccardo</creatorcontrib><creatorcontrib>Ghessi, Alberto</creatorcontrib><creatorcontrib>Gelosa, Franco</creatorcontrib><creatorcontrib>Iamoni, Gianmaria</creatorcontrib><creatorcontrib>Ideo, Gaetano</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zavaglia, Claudio</au><au>Bortolon, Cristina</au><au>Ferrioli, Gabriella</au><au>Rho, Anna</au><au>Mondazzi, Luca</au><au>Bottelli, Riccardo</au><au>Ghessi, Alberto</au><au>Gelosa, Franco</au><au>Iamoni, Gianmaria</au><au>Ideo, Gaetano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA typing in chronic type B, D and C hepatitis</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>24</volume><issue>6</issue><spage>658</spage><epage>665</epage><pages>658-665</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Aims: We aimed to test the hypothesis that susceptibility to chronic HBV, HDV or HCV infections or their pathology is influenced by host genetic factors.
Methods: The Human Leukocyte Antigens (HLA) (A, B, DR and DQ) were determined by microlym- phocytotoxicity assay in patients with chronic C (
n=117), B (
n=97) or D (
n=27) hepatitis and their frequencies were compared with those of 489 healthy controls.
Results: No statistically significant association was found between any HLA antigen and chronic B or D hepatitis. A significantly higher frequency of HLA-B14 was observed in patients with chronic persistent or active C hepatitis (16.7% of 90 versus 5.9% of 489, χ
2=10.9,
pc<0.05, Relative Risk=3.17, Etiological Fraction=0.11). The frequency of HLA-DR5 was lower in HCV positive patients (24.8%) than in controls (45%, χ
2=15.1,
pc<0.005, RR=0.4, EF=−0.37).
Conclusions: No correlation could be observed between clearance of HBV or HDV and HLA phenotype. Immunogenetic factors may have a role in determining susceptibility to chronic HCV hepatitis, and in Italian patients HLA-DR5 is a protective factor.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>8835739</pmid><doi>10.1016/S0168-8278(96)80260-1</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 1996-06, Vol.24 (6), p.658-665 |
| issn | 0168-8278 1600-0641 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78373556 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Aged Antibodies, Viral - analysis Biological and medical sciences Biopsy Chronic Disease Chronic hepatitis DNA, Viral - analysis Enzyme-Linked Immunosorbent Assay Female HBV HCV HDV Hepatitis B - immunology Hepatitis B - pathology Hepatitis B - therapy Hepatitis C - immunology Hepatitis C - pathology Hepatitis C - therapy Hepatitis D - immunology Hepatitis D - pathology Hepatitis D - therapy Hepatitis Viruses - genetics Hepatitis Viruses - immunology Hepatitis Viruses - isolation & purification Histocompatibility Testing - methods HLA HLA Antigens - drug effects HLA Antigens - immunology Human viral diseases Humans Immunoblotting Immunophenotyping Infectious diseases Interferons - therapeutic use Male Medical sciences Middle Aged Radioimmunoassay Retrospective Studies Viral diseases Viral hepatitis |
| title | HLA typing in chronic type B, D and C hepatitis |
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