HLA typing in chronic type B, D and C hepatitis

Aims: We aimed to test the hypothesis that susceptibility to chronic HBV, HDV or HCV infections or their pathology is influenced by host genetic factors. Methods: The Human Leukocyte Antigens (HLA) (A, B, DR and DQ) were determined by microlym- phocytotoxicity assay in patients with chronic C ( n=11...

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Veröffentlicht in:	Journal of hepatology 1996-06, Vol.24 (6), p.658-665
Hauptverfasser:	Zavaglia, Claudio, Bortolon, Cristina, Ferrioli, Gabriella, Rho, Anna, Mondazzi, Luca, Bottelli, Riccardo, Ghessi, Alberto, Gelosa, Franco, Iamoni, Gianmaria, Ideo, Gaetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibodies, Viral - analysis Biological and medical sciences Biopsy Chronic Disease Chronic hepatitis DNA, Viral - analysis Enzyme-Linked Immunosorbent Assay Female HBV HCV HDV Hepatitis B - immunology Hepatitis B - pathology Hepatitis B - therapy Hepatitis C - immunology Hepatitis C - pathology Hepatitis C - therapy Hepatitis D - immunology Hepatitis D - pathology Hepatitis D - therapy Hepatitis Viruses - genetics Hepatitis Viruses - immunology Hepatitis Viruses - isolation & purification Histocompatibility Testing - methods HLA HLA Antigens - drug effects HLA Antigens - immunology Human viral diseases Humans Immunoblotting Immunophenotyping Infectious diseases Interferons - therapeutic use Male Medical sciences Middle Aged Radioimmunoassay Retrospective Studies Viral diseases Viral hepatitis
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Beschreibung
Zusammenfassung:	Aims: We aimed to test the hypothesis that susceptibility to chronic HBV, HDV or HCV infections or their pathology is influenced by host genetic factors. Methods: The Human Leukocyte Antigens (HLA) (A, B, DR and DQ) were determined by microlym- phocytotoxicity assay in patients with chronic C ( n=117), B ( n=97) or D ( n=27) hepatitis and their frequencies were compared with those of 489 healthy controls. Results: No statistically significant association was found between any HLA antigen and chronic B or D hepatitis. A significantly higher frequency of HLA-B14 was observed in patients with chronic persistent or active C hepatitis (16.7% of 90 versus 5.9% of 489, χ 2=10.9, pc
ISSN:	0168-8278 1600-0641
DOI:	10.1016/S0168-8278(96)80260-1