Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells
Tuna muscle-derived angiotensin-converting enzyme inhibitory peptide, PTHIKWGD, inhibited the injury of bovine aorta endothelial cells (BAECs) induced by N-formyl-methionyl-leucyl-phenylalanine-activated polymorphonuclear leukocytes and the adhesion of a leukemia cell line, THP-1 cells, to BAECs sti...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1996/01/15, Vol.19(1), pp.139-141 |
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| container_end_page | 141 |
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| container_issue | 1 |
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| container_title | Biological & pharmaceutical bulletin |
| container_volume | 19 |
| creator | KOHAMA, Yasuhiro KURODA, Takayuki ITOH, Susumu MIMURA, Tsutomu |
| description | Tuna muscle-derived angiotensin-converting enzyme inhibitory peptide, PTHIKWGD, inhibited the injury of bovine aorta endothelial cells (BAECs) induced by N-formyl-methionyl-leucyl-phenylalanine-activated polymorphonuclear leukocytes and the adhesion of a leukemia cell line, THP-1 cells, to BAECs stimulated by lipopolysaccharides. It is possible that this peptide directly affects BAECs, protecting them from activated leukocytes. |
| doi_str_mv | 10.1248/bpb.19.139 |
| format | Article |
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It is possible that this peptide directly affects BAECs, protecting them from activated leukocytes.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.19.139</identifier><identifier>PMID: 8820927</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; Biological and medical sciences ; Cattle ; cell adhesion ; Cell Adhesion - drug effects ; cell injury ; Cells, Cultured ; endothelial cell ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; General pharmacology ; Guinea Pigs ; Humans ; leukocyte ; Leukocytes - drug effects ; Leukocytes - physiology ; Lipopolysaccharides - pharmacology ; Marine ; Medical sciences ; N-Formylmethionine Leucyl-Phenylalanine - pharmacology ; Oligopeptides - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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It is possible that this peptide directly affects BAECs, protecting them from activated leukocytes.</description><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>cell adhesion</subject><subject>Cell Adhesion - drug effects</subject><subject>cell injury</subject><subject>Cells, Cultured</subject><subject>endothelial cell</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>General pharmacology</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>leukocyte</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - physiology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Marine</subject><subject>Medical sciences</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</subject><subject>Oligopeptides - pharmacology</subject><subject>Pharmacognosy. 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Drug treatments</topic><topic>Thunnidae</topic><topic>Tuna - metabolism</topic><topic>tuna peptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOHAMA, Yasuhiro</creatorcontrib><creatorcontrib>KURODA, Takayuki</creatorcontrib><creatorcontrib>ITOH, Susumu</creatorcontrib><creatorcontrib>MIMURA, Tsutomu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOHAMA, Yasuhiro</au><au>KURODA, Takayuki</au><au>ITOH, Susumu</au><au>MIMURA, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1996-01-01</date><risdate>1996</risdate><volume>19</volume><issue>1</issue><spage>139</spage><epage>141</epage><pages>139-141</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Tuna muscle-derived angiotensin-converting enzyme inhibitory peptide, PTHIKWGD, inhibited the injury of bovine aorta endothelial cells (BAECs) induced by N-formyl-methionyl-leucyl-phenylalanine-activated polymorphonuclear leukocytes and the adhesion of a leukemia cell line, THP-1 cells, to BAECs stimulated by lipopolysaccharides. It is possible that this peptide directly affects BAECs, protecting them from activated leukocytes.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8820927</pmid><doi>10.1248/bpb.19.139</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological and Pharmaceutical Bulletin, 1996/01/15, Vol.19(1), pp.139-141 |
| issn | 0918-6158 1347-5215 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Cattle cell adhesion Cell Adhesion - drug effects cell injury Cells, Cultured endothelial cell Endothelium, Vascular - cytology Endothelium, Vascular - drug effects General pharmacology Guinea Pigs Humans leukocyte Leukocytes - drug effects Leukocytes - physiology Lipopolysaccharides - pharmacology Marine Medical sciences N-Formylmethionine Leucyl-Phenylalanine - pharmacology Oligopeptides - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Thunnidae Tuna - metabolism tuna peptide |
| title | Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells |
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