Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells

Tuna muscle-derived angiotensin-converting enzyme inhibitory peptide, PTHIKWGD, inhibited the injury of bovine aorta endothelial cells (BAECs) induced by N-formyl-methionyl-leucyl-phenylalanine-activated polymorphonuclear leukocytes and the adhesion of a leukemia cell line, THP-1 cells, to BAECs sti...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1996/01/15, Vol.19(1), pp.139-141
Hauptverfasser:	KOHAMA, Yasuhiro, KURODA, Takayuki, ITOH, Susumu, MIMURA, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Cattle cell adhesion Cell Adhesion - drug effects cell injury Cells, Cultured endothelial cell Endothelium, Vascular - cytology Endothelium, Vascular - drug effects General pharmacology Guinea Pigs Humans leukocyte Leukocytes - drug effects Leukocytes - physiology Lipopolysaccharides - pharmacology Marine Medical sciences N-Formylmethionine Leucyl-Phenylalanine - pharmacology Oligopeptides - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Thunnidae Tuna - metabolism tuna peptide
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Zusammenfassung:	Tuna muscle-derived angiotensin-converting enzyme inhibitory peptide, PTHIKWGD, inhibited the injury of bovine aorta endothelial cells (BAECs) induced by N-formyl-methionyl-leucyl-phenylalanine-activated polymorphonuclear leukocytes and the adhesion of a leukemia cell line, THP-1 cells, to BAECs stimulated by lipopolysaccharides. It is possible that this peptide directly affects BAECs, protecting them from activated leukocytes.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.19.139