Effect of doxazosin on fibrinolysis in hypertensive patients with and without insulin resistance

The fibrinolytic and metabolic changes associated with doxazosin treatment were evaluated in 20 patients with mild to moderate hypertension. Steady-state plasma glucose (SSPG) concentration was used to subdivide hypertensive patients into two groups of 10 each: insulin-resistant (SSPG >190 mg/dl)...

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Veröffentlicht in:	The American heart journal 1996-10, Vol.132 (4), p.783-789
Hauptverfasser:	Jeng, Jing-Ren, Sheu, Wayne Huey-Herng, Jeng, Chii-Yuan, Huang, Shyuh-Hyei, Shieh, Shyh-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - therapeutic use Antihypertensive agents Antihypertensive Agents - therapeutic use Biological and medical sciences Blood Glucose - metabolism Cardiovascular system Case-Control Studies Doxazosin - therapeutic use Female Fibrinolysis - drug effects Humans Hypertension - blood Hypertension - drug therapy Hypertension - metabolism Insulin Resistance Lipids - blood Male Medical sciences Middle Aged Pharmacology. Drug treatments Plasminogen Activator Inhibitor 1 - blood Time Factors Tissue Plasminogen Activator - blood
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Zusammenfassung:	The fibrinolytic and metabolic changes associated with doxazosin treatment were evaluated in 20 patients with mild to moderate hypertension. Steady-state plasma glucose (SSPG) concentration was used to subdivide hypertensive patients into two groups of 10 each: insulin-resistant (SSPG >190 mg/dl) and nonresistant (SSPG
ISSN:	0002-8703 1097-6744
DOI:	10.1016/S0002-8703(96)90312-9