Physical analysis of the region deleted in the tW18 allele of the mouse tcl-4 complementation group

We have generated a YAC contig of at least 3.3 Mb from the proximal region of In(17)4 of mouse chromosome 17. This region corresponds to DNA lost in the gastrulation mutant tw18, which belongs to the tcl-4 complementation group. Our most proximal and distal probes lie within the deletion-3.3 Mb apar...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1996-08, Vol.36 (1), p.39-46
Hauptverfasser:	BARCLAY, J, KING, T. F, CROSSLEY, P. H, BARNARD, R. C, LARIN, Z, LEHRACH, H, LITTLE, P. F. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biological and medical sciences Chromosome Deletion Chromosome Walking Chromosomes, Artificial, Yeast - genetics Classical genetics, quantitative genetics, hybrids DNA Probes Embryonic and Fetal Development - genetics Fundamental and applied biological sciences. Psychology Gastrula Genetic Complementation Test Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Mice Mice, Inbred C57BL Recombination, Genetic Restriction Mapping Vertebrata
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Zusammenfassung:	We have generated a YAC contig of at least 3.3 Mb from the proximal region of In(17)4 of mouse chromosome 17. This region corresponds to DNA lost in the gastrulation mutant tw18, which belongs to the tcl-4 complementation group. Our most proximal and distal probes lie within the deletion-3.3 Mb apart-indicating that we have not cloned the entire region. The deleted region is contained in a genetic interval of less than 1 cM, suggesting that some suppression of recombination must occur.
ISSN:	0888-7543 1089-8646