Analogs of cell surface carbohydrates. Synthesis of d-galactose derivatives having an ethynyl, vinyl or epoxy residue at C-5

Compounds derived from d-galactose having an ethynyl, vinyl, or epoxide residue at C-5, as well as 7,7-dibromo olefinic, isomeric 7,7- gem-bromofluoro olefinic, and 6,6- gem-difluoro derivatives were obtained from 1,2:3,4-di- O-isopropylidene-α- d- galacto-hexodialdo-1,5-pyranose.

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Bibliographische Detailangaben
Veröffentlicht in:	Carbohydrate research 1988-05, Vol.176 (1), p.59-72
Hauptverfasser:	Lee, Ho H., Hodgson, Philip G., Bernacki, Ralph J., Korytnyk, Walter, Sharma, Moheswar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemical synthesis Animals Antineoplastic Agents - chemical synthesis Cell Membrane - drug effects Drug Screening Assays, Antitumor Epoxy Compounds - chemical synthesis Galactose - analogs & derivatives Galactose - chemical synthesis Galactose - therapeutic use Indicators and Reagents Leukemia L1210 - drug therapy Magnetic Resonance Spectroscopy Mice Vinyl Compounds - chemical synthesis
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Beschreibung
Zusammenfassung:	Compounds derived from d-galactose having an ethynyl, vinyl, or epoxide residue at C-5, as well as 7,7-dibromo olefinic, isomeric 7,7- gem-bromofluoro olefinic, and 6,6- gem-difluoro derivatives were obtained from 1,2:3,4-di- O-isopropylidene-α- d- galacto-hexodialdo-1,5-pyranose.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/0008-6215(88)84057-6