Diversity and function of presynaptic calcium channels in the brain

Diversity and function of presynaptic calcium channels in the brain

Calcium channels in presynaptic nerve terminals are essential for neurotransmitter release, and current research has provided evidence for the involvement of a multitude of Ca 2+ channel types. The diversity of Ca 2+ channel structure and distribution in the brain suggests specific functional roles....

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Veröffentlicht in:Current opinion in neurobiology 1996-06, Vol.6 (3), p.331-337
1. Verfasser: Reuter, Harald
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - metabolism
Calcium Channels - genetics
Calcium Channels - physiology
Presynaptic Terminals - metabolism
Tissue Distribution
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Beschreibung
Zusammenfassung:Calcium channels in presynaptic nerve terminals are essential for neurotransmitter release, and current research has provided evidence for the involvement of a multitude of Ca 2+ channel types. The diversity of Ca 2+ channel structure and distribution in the brain suggests specific functional roles. Modulation by interaction with other proteins and/or by phosphorylation/dephosphorylation reactions enhances the regulatory impact of these channels on brain function.
ISSN:0959-4388
1873-6882
DOI:10.1016/S0959-4388(96)80116-4