Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?

Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. A...

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Veröffentlicht in:	Surgical neurology 1988-08, Vol.30 (2), p.125-130
Hauptverfasser:	Raffel, Corey, Boggan, James E., Eng, Lawrence F., Davis, Richard L., Wilson, Charles B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - etiology Adenoma - metabolism Adenoma - pathology Adrenocorticotropic Hormone - metabolism Antibodies, Monoclonal Axons - ultrastructure Biological and medical sciences Cushing Syndrome - etiology Cushing Syndrome - pathology Cushing's disease Endocrinopathies Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Intermediate Filaments - immunology Intermediate lobe Malignant tumors Medical sciences Monoclonal antibody Pituitary Gland - metabolism Pituitary Gland - pathology Pituitary Neoplasms - etiology Pituitary Neoplasms - metabolism Pituitary Neoplasms - pathology Staining and Labeling - methods
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Zusammenfassung:	Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.
ISSN:	0090-3019 1879-3339
DOI:	10.1016/0090-3019(88)90097-3