Evidence for adenosine A1 receptor action in rat jejunal mucosa

Cyclic AMP was elevated in rat jejunal mucosa in the presence of adenosine deaminase (2 mg/1) both alone or under conditions of stimulated mucosal cyclic AMP accumulation (forskolin 20 microM/papaverine 100 microM). The effects of adenosine deaminase were reversed by (-)-N6-phenylisopropyl-adenosine...

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Veröffentlicht in:	European journal of pharmacology 1988-04, Vol.149 (1-2), p.155-158
Hauptverfasser:	REYMANN, A, GNIESS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine Deaminase - metabolism Adenosine-5'-(N-ethylcarboxamide) Animals Biological and medical sciences Colforsin - pharmacology Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology In Vitro Techniques Intestinal Mucosa - metabolism Intestine. Mesentery Jejunum - metabolism Male Papaverine - pharmacology Phenylisopropyladenosine - pharmacology Rats Rats, Inbred Strains Receptors, Purinergic - metabolism Theophylline - pharmacology Vasodilator Agents - pharmacology Vertebrates: digestive system
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Zusammenfassung:	Cyclic AMP was elevated in rat jejunal mucosa in the presence of adenosine deaminase (2 mg/1) both alone or under conditions of stimulated mucosal cyclic AMP accumulation (forskolin 20 microM/papaverine 100 microM). The effects of adenosine deaminase were reversed by (-)-N6-phenylisopropyl-adenosine (PIA, 10 microM). This action of PIA on mucosal cyclic AMP was antagonized by theophylline (1 mM) and was insensitive to tetrodotoxin (100 nM). The potency of PIA was 100-fold higher than that of 5'-N-ethylcarboxamido-adenosine (NECA). It is suggested that adenosine A1 receptors are present in rat jejunal mucosal cells.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(88)90055-6