In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450

Famotidine, 3-(((2((aminoiminomethyl)amino)-4-thiazoyl)methyl)thiol)-N-(aminos ulfonyl) propanimidamide, is a new H sub(2)-receptor antagonist and has been shown to be more potent and longer-lasting than cimetidine. To examine the potential of drug interactions in vivo, the in vitro interaction of f...

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Veröffentlicht in:	Biochemical pharmacology 1988-08, Vol.37 (15), p.3049-3053
Hauptverfasser:	Wang, Regina W., Miwa, Gerald T., Argenbright, Lois S., Lu, Anthony Y.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cimetidine - metabolism Cytochrome P-450 Enzyme System - metabolism Digestive system Famotidine Histamine H2 Antagonists - metabolism Humans liver Male Medical sciences Methylcholanthrene - administration & dosage Microsomes, Liver - metabolism Oxidation-Reduction Pharmacology. Drug treatments Phenobarbital - administration & dosage Rats Rats, Inbred Strains Spectrum Analysis Thiadiazoles - metabolism Thiazoles - metabolism
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Zusammenfassung:	Famotidine, 3-(((2((aminoiminomethyl)amino)-4-thiazoyl)methyl)thiol)-N-(aminos ulfonyl) propanimidamide, is a new H sub(2)-receptor antagonist and has been shown to be more potent and longer-lasting than cimetidine. To examine the potential of drug interactions in vivo, the in vitro interaction of famotidine with rat and human liver microsomal cytochrome P-450 and its subsequent inhibition of drug metabolism were compared with those of cimetidine.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(88)90298-5