Vitamin E inhibits protein kinase c activity

Vitamin E (dl-α-tocopherol) has been found to inhibit in vitro brain protein kinase c with a half inhibitory concentration of 450 μM. The known plasma concentrations of vitamin E are one order of magnitude lower than the protein kinase c half-inhibitory concentration but it is also known that, at th...

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Veröffentlicht in:	Biochemical and biophysical research communications 1988-07, Vol.154 (2), p.694-697
Hauptverfasser:	Mahoney, Charles W., Azzi, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Calcium - metabolism Cattle Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Phospholipids - metabolism protein kinase C Protein Kinase C - metabolism Transferases vitamin E Vitamin E - pharmacology
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Zusammenfassung:	Vitamin E (dl-α-tocopherol) has been found to inhibit in vitro brain protein kinase c with a half inhibitory concentration of 450 μM. The known plasma concentrations of vitamin E are one order of magnitude lower than the protein kinase c half-inhibitory concentration but it is also known that, at the membrane level where the active protein kinase c is located, the lipophilic vitamin E is more concentrated (Burton, G.W., Joyce, A. and Ingold, K.U. and Locke, S. (1983) Arch. Biochem. Biophys. 221, 281–290). It appears that vitamin E, in addition to its antioxidant function, may play a role in regulating the activity of protein kinase c.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(88)90195-7