Partial amino acid sequence of rat topoisomerase I: Comparison with the predicted sequences for the human and yeast enzymes

The partial amino acid sequence of rat topoisomerase I was determined by gas-phase microsequencing. Seven tryptic peptides closely matched the sequences deduced from human topoisomerase I cDNA (94.5% homology). Similarity to sequences deduced from baker's yeast and fission yeast genomic DNA wer...

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Veröffentlicht in:	Biochemical and biophysical research communications 1988-07, Vol.154 (1), p.358-364
Hauptverfasser:	Durban, Egon, Bramucci, Massimo, Cook, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods DNA - genetics DNA Topoisomerases, Type I - genetics Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans Isomerases Liver Neoplasms, Experimental - enzymology Molecular Sequence Data Peptide Fragments - analysis Rats Saccharomyces cerevisiae - enzymology Schizosaccharomyces - enzymology Species Specificity Trypsin
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