Antiviral Activity of Some Hydroxycoumarin Derivatives

Esculetin (6,7-dihydroxycoumarin) and its diacetate exhibited a marked inhibitory effect on Newcastle disease virus replication in cell cultures at concentrations of 36 jam and 62 jam, respectively. These compounds were selected from ten hydroxycoumarin derivatives through an in vitro antiviral scre...

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Veröffentlicht in:	Zeitschrift für Naturforschung C. A journal of biosciences 1996-08, Vol.51 (7), p.558-562
Hauptverfasser:	Galabov, Angel S., Iosifova, Tanya, Vassileva, Elka, Kostova, Ivanka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Bulgaria Cell Line Cell Survival - drug effects Cells, Cultured Chick Embryo Coumarins - chemistry Coumarins - isolation & purification Coumarins - pharmacology Esculetin. Antiviral Herpesvirus 1, Suid - drug effects Hydroxycoumarin in vitro Screening Influenza A virus - drug effects Magnetic Resonance Spectroscopy Molecular Structure Newcastle disease virus - drug effects Newcastle disease virus - physiology Plant Extracts Plant Stems Poliovirus - drug effects Spectrophotometry, Infrared Trees Virus Replication - drug effects
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Beschreibung
Zusammenfassung:	Esculetin (6,7-dihydroxycoumarin) and its diacetate exhibited a marked inhibitory effect on Newcastle disease virus replication in cell cultures at concentrations of 36 jam and 62 jam, respectively. These compounds were selected from ten hydroxycoumarin derivatives through an in vitro antiviral screen involving viruses of the picorna-, orthomyxo-, paramyxo-, and herpes virus families.
ISSN:	0939-5075 1865-7125
DOI:	10.1515/znc-1996-7-815