Elevated frequency of the C2 allele of the ETS-I oncogene in elderly subjects

Elevated frequency of the C2 allele of the ETS-I oncogene in elderly subjects

We studied the frequency of an S stI polymorphism of the ETS-1 oncogene in 122 elderly subjects (mean age 78.14 years) and 115 teenagers (mean age 16.9 years). No difference in the frequency of the three genotypes (C1C1, C1C2, C2C2) was found between the two groups. However, the C2 allele occurred m...

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Veröffentlicht in:Mechanisms of ageing and development 1996-07, Vol.88 (1), p.61-65
Hauptverfasser: Crossen, Peter E., Morrison, Mary J.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Aged, 80 and over
Aging - physiology
Alleles
Biological and medical sciences
C2 allelle
Classical genetics, quantitative genetics, hybrids
Elderly
ETS-I oncogene
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Male
Oncogenes
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-ets
Transcription Factors - genetics
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Zusammenfassung:We studied the frequency of an S stI polymorphism of the ETS-1 oncogene in 122 elderly subjects (mean age 78.14 years) and 115 teenagers (mean age 16.9 years). No difference in the frequency of the three genotypes (C1C1, C1C2, C2C2) was found between the two groups. However, the C2 allele occurred more frequently in the elderly subjects ( χ 2=5.49, P
ISSN:0047-6374
1872-6216
DOI:10.1016/0047-6374(96)01721-6