Efficacy of multiple-dose halofantrine in treatment of chloroquine resistant falciparum malaria in children in Kenya

Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45.4 h and 54.8 h, respectively. In-vitro chemosensitivity tests sh...

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Veröffentlicht in:	The Lancet (British edition) 1988-07, Vol.2 (8605), p.247-250
Hauptverfasser:	WATKIN, W. M, OLOO, J. A, LURY, J. D, MOSOBA, M, KARIUKI, D, MJOMBA, M, KOECH, D. K, GILLES, H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - administration & dosage Antimalarials - therapeutic use Antiparasitic agents Biological and medical sciences Child Child, Preschool Chloroquine - therapeutic use Clinical Trials as Topic Drug Administration Schedule Drug Evaluation Drug Resistance Female Follow-Up Studies Half-Life Human protozoal diseases Humans Infant Infectious diseases Kenya Malaria Malaria - blood Malaria - drug therapy Malaria - epidemiology Malaria - urine Male Medical sciences Parasitic diseases Pharmacology. Drug treatments Phenanthrenes - administration & dosage Phenanthrenes - therapeutic use Plasmodium falciparum Prevention and actions Protozoal diseases Public health. Hygiene Public health. Hygiene-occupational medicine Specific populations (family, woman, child, elderly...) Time Factors Tropical medicine
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Zusammenfassung:	Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45.4 h and 54.8 h, respectively. In-vitro chemosensitivity tests showed that most infections were due to chloroquine-resistant parasites, and that parasite maturation was inhibited by considerably lower concentrations of halofantrine than of chloroquine.
ISSN:	0140-6736 1474-547X