Transcriptional autoregulation of the proto-oncogene fos

Transcriptional autoregulation of the proto-oncogene fos

Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos...

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Veröffentlicht in:Nature (London) 1988-07, Vol.334 (6180), p.314-319
Hauptverfasser: Sassone-Corsi, Paolo, Sisson, John C, Verma, Inder M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Base Sequence
Biological and medical sciences
Blood
Cellular biology
DNA Restriction Enzymes - metabolism
Fundamental and applied biological sciences. Psychology
Heat-Shock Proteins - genetics
Humans
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Promoter Regions, Genetic
Proteins
Proto-Oncogenes
Transcription, Genetic
Transcription. Transcription factor. Splicing. Rna processing
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Beschreibung
Zusammenfassung:Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos protein.
ISSN:0028-0836
1476-4687
DOI:10.1038/334314a0